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Theses/Dissertations from 2026

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Structural Insights into Host-Pathogen Interactions of Coronaviruses and Alphaviruses, Lucas Adams

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Role of Mesencephalic Reticular Formation Perineuronal Nets in Nociception, Migraine and Alcohol Withdrawal-induced Hyperalgesia, Jhoan Aguilar

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Phylogenomic Insights into the Evolution, Biogeography, Systematics, and Taxonomy of Weinmannia (Cunoniacea) in the Neotropics, Eduardo Aguirre Mazzi

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Inside 'n Out: ETV2 Specification of Hemangiogenic Lineages from FLK1+ Mesoderm, Dereck Antonio Shakeel Alleyne

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Using single cell multi omics and spatial transcriptomics to characterize the inflammatory- fibroblast axis in cardiovascular disease, Junedh Mahesh Amrute

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Valuation in Time: Mesolimbic Dopamine tracks Decision Strategy, Commitment and Persistence, Apoorva Arora

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Function, Regulation and Plasticity of Reactive Microglial States in Brain Development and Disease, Kia Marie Barclay

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Genetic Mechanisms of Urinary Tract Infection Pathogenesis by Escherichia coli, Jesus Bazan Villicana

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More than one way to keep an ILC in Line: Circadian and Epigenetic regulation of group 3 ILCs homeostasis, Bishan Bhattarai

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Aberrant Activity of the Calcium Sensor STIM1 Drives Thrombocytopenia and Bone Marrow Fibrosis in Stormorken Syndrome, Molly Brakhane

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The Invisible Crop: Harnessing Root System Architecture in Heirloom Collards for Climate-Resilient Urban Agriculture, Vincent Antonio Brazelton

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Impacts of Anthropogenic Landscape Change on Plant-Associated Microbes, Mahal Bugay

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Unraveling the Role of the C-Terminal Intrinsically Disordered Linker in the Bacterial Cell Division Protein FtsZ, Jessica Louise Bullock

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Dissecting the Roles of Microglial Proteostasis and Innate Immune Signaling in Neurodegeneration, Zhangying Cai

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Interplay Between Patterning and Morphogenesis During Zebrafish Embryonic Development, Chia-Teng Chang

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Understanding Whole-Brain Dynamics Through Generative Modeling, Ruiqi Chen

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Piloting a Scalable Workflow to Identify Drivers of Mammalian Aging Using C. Elegans, Ariella Lucia Coler-Reilly Colasanti

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Incorporating Pectic Glycans into Microbiome-Directed Therapeutic Foods for Childhood Undernutrition, Marie Crane

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Dissecting MS4A4A Function in Microglia and its Role in Alzheimer’s Disease Pathogenesis, Emma Pascal Danhash

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Investigating Tumor-stromal Interactions that Drive Breast Cancer Angiogenesis and Metastasis, Alessandra DiMauro

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From Bench to Bedside: Unraveling the Role of SARM1 in Chronic Human Neurodegenerative Disease, Caitlin Dingwall

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The Function and Regulation of LAIR1 and LAIR2 in Inflammation and Staphylococcus aureus Infection, Hannah Dorando

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Development of Cell-Free DNA and Immune Cell Liquid Biopsies to Stratify Risk of Disease Progression and Treatment Toxicity, Noah Earland

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Hematopoietic Stem and Progenitor Cell Reprogramming During Breast Cancer Progression Promotes Myeloid-Biased Hematopoiesis, Emily Maria Eul

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Retinal Circuits for Pupil Control: Neural Mechanisms, Visual Functions, and Capacity for Plasticity, Michael John Fitzpatrick

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Aspartic Protease Inhibition as an Anti-Malarial Strategy, Katherine Lillie Floyd

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Apoptotic cells as a physiological source of β-alanine to modulate MrgprD-expressing sensory neurons, Sofia L. Gasperino

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Elucidating the Coordinated Role of Histone Modifications on the Establishment and Regulation of a Neuronal-specific Methylome, Nicole Hamagami

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Diversity and Regulation of Biosynthetic Gene Clusters for Polycyclic Tetramate Macrolactams, CHRISTOPHER PATRICK HARPER

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Characterizing the Epigenomic and Transposable Element Landscapes of Human Cytotrophoblasts and Syncytiotrophoblasts during gestation and in the pathology: Severe Preeclampsia, Jessica Harrison

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Investigating the Intra-host Relationships of the Microbiota at Multiple Sites, Ariel Jose Hernandez-Leyva

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Combined Flt3L and CD40 Agonism Restores Dendritic Cell Driven T Cell Immunity in Mouse Models and Patients With Pancreatic Cancer, Graham Hogg

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Investigating the Regulatory Functions of Long Noncoding RNAs in Retinal Development, Jade Hostetler

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Evaluating RNA-Targeted Splicing Correction, Proteasomal Clearance, and Biomarker Profiling in Neurodegeneration, Miwei Hu

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The Role of lncRNA, RAMS11, in KEAP1-Mutant Non-Small Cell Lung Cancer, Gejae George Jeffers

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Ribosomal Stress in the Pathogenesis and Treatment of T-cell Acute Lymphoblastic Leukemia, Kimberly Bridget Johansson

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The Role of Autophagy in Intestinal Infection in Mice and C. elegans, Gowri Kalugotla

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Mass Spectrometry Profiling and High-Throughput Sequencing of HDACi-Induced Histone Modification Changes, Rashmi Karki

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A ‘Don’t Eat Too Much’ Signal in Phagocytes via the SIRP⍺-SHP2 Axis Tunes Efferocytosis of Apoptotic Cells, Shannon Kelley

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Reprogramming of Myeloid Cells for Anti-Tumor Immunity, Darya Khantakova

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An In Vivo Framework for Decoding the Regulatory Logic of RNA Localization and Local Translation in Astrocytes: From Cis-Regulatory Sequences to Trans-Acting Factors, Sarah Kathleen Koester

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Atypical Genetic Mechanisms: Uniparental Disomy, Somatic Mosaicism, and Mitochondrial Variation, Na Hyun Kong

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Targeting the DNMT3B-ABAT Axis in Osteoarthritis Using RNA-peptide Nanoparticles Reveals GABAB Signaling as a Critical Mediator of Articular Chondrocyte Homeostasis, Amir Kucharski

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Characterizing the Brain's Functional Architecture in Early Infancy, Alyssa Kimberly Labonte

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Molecular mechanisms and factors regulating plant DNA methylation, Huy Le

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The defining role of AGO4 and its catalytic activity during de novo RNA-directed DNA methylation, Tianyi Li

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Learning Sequence Constraints Governing Conformational Ensembles and Function in Intrinsically Disordered Proteins, Jeffrey Lotthammer

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Understanding brain borders, Tornike Mamuladze

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Disclosing Metabolic Sex Differences in Brain Cancer: Optimization of Amino Acid, Purine, and Pyrimidine Metabolism as a Targetable Sex Difference, Camryn Tyler Marquez

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Development and Applications of Optical Imaging Approaches for the Tumor Microenvironment, Megan Suzanne Michie

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Macroevolutionary Innovation and the Genomic Basis of Convergent Adaptation in Anolis Lizards, Aryeh Hershel Miller

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Molecular Regulation of the Tcf7-Prdm1 Axis in CD8+ T Cells, Maegan Katherine Murphy

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Supporting the next generation: bHLH TF complexes regulating maize anther development, Lily Elizabeth O'Connor

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Molecular Mechanism of WDFY4-Mediated Cross-Presentation by Type 1 Conventional Dendritic Cells, Ray Andrew Ohara

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The Gut-Bladder Axis: How Symbiont Microbes Alter Urinary Tract Infections, Benjamin S. Olson

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Molecular Circuits in Dendritic Cell Development, Feiya Ou

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Contextual Coding in the Prefrontal Cortex, Jeong Jun Park

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Spontaneous Blood Oxygen Level Dependent Signals in Glioblastoma-bearing and Aging Brains, Ki Yun Park

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Rapid induction of blastoid-competent naïve human pluripotent stem cells and their application to investigate BAF complex function during early lineage specification, Kyoung Mi Park

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Convergent RNA Pathophysiology in Amyotrophic Lateral Sclerosis, Hunter Lee Patterson

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Synaptic enrichment and diagnostic potential of circular RNA in Alzheimer’s Disease, Bridget Mattie Phillips

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Uncovering Hidden Features of Copyback Viral Genomes, Sarah Pye

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Understanding p53 Regulation on Transposable Elements in Cancer, Xuan Qu

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Defining Replication-Driven Vulnerabilities in High Grade Serous Ovarian Cancers, Natasha Maya Ramakrishnan

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Astrocyte Circadian Regulation in Neurodegeneration: In Vivo BMAL1 Occupancy Mapping Using MACS-Calling Cards, India Reiss

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Understanding the Effects of Antibiotics and Disease to the Human Gut Microbiome During Development and Aging, Jian Ryou

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CpsA-dependent remodeling of host lysosomal trafficking in Mycobacterium tuberculosis, Jully Jitendra Sadadiwala

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Epigenetic Mechanisms of Response and Resistance to Therapy in Head and Neck Squamous Cell Carcinoma, Reilly Sample

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Programming of the Pre-B Cell Checkpoint and Maintenance of B Cell Development by DNA Damage Responses, Haley Schmidt

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Development of a Quantitative Top-Down Proteomics Platform for Arginylated Proteoform Analysis, Richard Myer Searfoss

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Multiplex Functional Assessment of Variant Effect in the Retinal Transcription Factor CRX, James Lewis Shepherdson

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Elucidating the Distinct Roles of EZH2 Gain-of-Function Events in Germinal Center B cells, Sofia R. Smith

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MTHFD2 is a selective metabolic vulnerability in AML, Judith Obiageli Sokei

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Personalized Neoantigen Vaccine-Based Therapies for B-Cell Lymphoma: A Proof-of-Concept Study in Syngeneic Mouse Models of A20 Lymphoma, Yuang Song

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BAP1 Loss Links MYC Activation, Stress Response Vulnerability, and Disease Progression in Kidney Cancer, Ilya Strunilin

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BPTF-Dependent Regulation of Vaccine-Induced B Cell Responses, Alexandria Sturtz

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Beyond Autophagic Dysregulation: VMA21 Deficiency Reveals Altered Vesicle Trafficking and Broadens the Pathogenic Framework of X-Linked Myopathy with Excessive Autophagy, Christian Suarez

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PERfect Timing: Metabolic Regulation by Hepatocyte Circadian Gene Period 1, Jiameng Sun

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How Species Evolve Through Space and Time: Designing and Disseminating Phylogenetic Methods for Historical Biogeography, Sarah Kathryn Swiston

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Scalable and Accurate Computational Frameworks for Complex Genetic Variants: From Repeat Expansion Discovery to Somatic Mosaicism Benchmarking, Zitian Tang

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Beyond Attachment: Endolysosomal Determinants of New World Arenavirus Entry and Fusion, Cassandra E. Thompson

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Bacterial Colonization of Medical Devices in the Urogenital Tract, Morgan Rose Wilt Timm

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Genetic and Observational Insights into Metabolic Alterations in Alzheimer’s Disease, Ciyang Wang

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Unraveling Metabolic Determinants of Isoniazid Susceptibility in Mycobacterium tuberculosis, Erin Rilu Wang

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Engineering Modular RNA Detection Systems in Living Cells: From Dual-Aptamer Reporters Toward a Programmable Sensor for Diverse Genetic Information, Geng Wang

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Epigenetic Regulators MLL3 and MLL4 Sustain Hematopoietic Stem Cell Multipotency, Helen Chenwei Wang

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GABAergic ventral pallidum neurons drive hedonic feeding and are required for obesity, Justin Guang Wang

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Chitinase variants establish environmental inflammatory lung conditioning, Yilin Wang

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Energetic Heterogeneity in Retinal Ganglion Cells: Role of Neuronal Activity and Implications for Resilience, Zelun Wang

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Understanding the Biological Functions of Dual-Localized Mitochondrial Phosphatase PPTC7, Lianjie Wei

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Transient activation of potent progenitor cells is required for spinal cord regeneration, Chase Alexander Weinholtz

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Astrocytic α7 Nicotinic Acetylcholine Receptor Signaling and its Contribution to Behavior, Yifan Wu

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Progenitor Response during Zebrafish Spinal Cord Regeneration, Yuxiao Xu

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Dissecting Tumor Evolution and Immune Composition in PRC2 Loss (H3K27me3 Loss) vs Retained MPNST, Kuangying Yang

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Genetic and Mechanistic Dissection of Missing-Self Killing by Natural Killer Cells, Jeesang Yoon

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Graph-AI Frameworks for Integrative Multi-Omics Data Analysis, Heming Zhang

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Characterization of Ebola Virus VP24-Host Protein Interactions, Junjie Zhao

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Dietary Manipulations of the Undernourished Infant Microbiome, Cyrus Zhou

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Circuit and Cytokine Regulation of Effort Allocation in Acute and Chronic Sickness States, Xiaoyue Zhu

Theses/Dissertations from 2025

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Montane β-diversity: Biodiversity through Space and Time in Earth’s Most Biodiverse Regions, Ethan Ray Abercrombie