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Theses/Dissertations from 2019

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Regulation of AUXIN RESPONSE FACTOR Activity, Samantha Kristine Powers

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Determining the Local Transcriptional Response to DNA Double-Strand Breaks, Caitlin Purman

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Lnc-ing long non-coding RNAs to functional roles in B cell biology and beyond, Sarah Catherine Pyfrom

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Investigating Biological Mechanisms of Radiation Resistance in Advanced Stage Cervical Cancer, Fiona Ruiz

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Neuronal stress pathways influence synaptic development and nervous system function in Drosophila melanogaster, Alexandra Russo

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Elucidation of the role of S100A8/A9 and neutrophils in chronic tuberculosis, Ninecia Scott

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An Evolving Epigenome that Determines Tissue and Cell Specificity, Renee Louise Sears

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Individual Differences in Human Brain Functional Network Organization, Benjamin A. Seitzman

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The Role of the ASCC Complex in the Alkylation Damage Response, Jennifer Soll

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ZIPT-7.1 and zinc signaling in sperm activation of Caenorhabditis elegans, Chieh-Hsiang Tan

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The impact of mRNA structure on tRNA selection and ribosome rescue, Erica Nicole Thomas

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Exploring Infant Leukemia through Exome Sequencing and an In Vitro Model of Hematopoietic Development, Mark Cannon Valentine

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Abiotic Niche-assembly as a Driver of Species Diversity and Relative Abundance in Temperate and Tropical Forests, Dilys Vela Diaz

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Mechanisms of Nestmate Recognition Cue Production in the European Honey Bee, Apis mellifera., Cassondra Leigh Vernier

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The Role of U2AF1 in Normal and Abnormal Hematopoiesis, Brian A. Wadugu

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The Role of Smc3 in Mouse Embryonic and Adult Hematopoiesis, Tianjiao Wang

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Activation of Toll-like Receptor 3 Translates to Long-term Post-viral Lung Disease, Xinyu Wang

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Expression and Function of snoRNAs in Acute Myeloid Leukemia, Wayne Alsworth Warner

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A neural network for uncertainty anticipation and information seeking, Jensen Kael White

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Diverse Far-Red Light Utilization Strategies in Cyanobacteria and Algae, Benjamin Martin Wolf

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Generation and Utilization of Diverse Memory B Cells After Flavivirus Challenges, Rachel Wong

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Physiologic and pathologic profiling of clonal variations, Wing Hing Wong

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Cyanogenesis and the Genetics of Local Adaptation in White Clover (Trifolium repens L.), Sara Jeanes Wright

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Mechanics of Phenotypic Aging Trajectories in C. elegans and Humans, William Zhang

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Secretory IgA Enhances Gut B Cells Priming and Systemic IgG Responses Towards Commensals, You Zhou

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FAST-Forward Protein Folding and Design: Development, Analysis, and Applications of the FAST Sampling Algorithm, Maxwell Isaac Zimmerman

Theses/Dissertations from 2018

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Negative Regulators of Colonic Peripheral Regulatory T Cell Development, Teresa Lei Ai

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A tail of two PanCancer projects: Somatic variant identification and driver gene discovery using TCGA, Matthew Hawkins Bailey

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Evaluation of Neurobiological Risk Factors for Alcohol Consumption; Convergent Evidence for Predispositional Effects of Brain Volume, David Baranger

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Preventing Extinction of At-Risk Plant Species in a Complex World, Holly Lee Bernardo

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Transcriptional Regulation of Dendritic Cell Function, Carlos Briseno

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Mapping Sterol Binding Sites in Integral Membrane Proteins using Mass Spectrometry, Melissa Marie Budelier

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The Essential Roles of the Chromatin Factor Gon4l in Heart Development, Terin Elise Budine

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A Mechanism of Antimicrobial Resistance and a Mitigation Strategy, Christopher Bulow

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Cancer genomics approaches elucidate tumor mutational and microenvironmental landscapes and dynamics, Katie Campbell

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CD4 T Cell Interaction with Intestinal Microbes under Homeostasis and Inflammation, Jiani Chai

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Integration of Local and Regional Regulatory Information in the Human Genome, Hemangi Govind Chaudhari

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A Mouse Model of Börjeson-Forssman-Lehmann Syndrome reveals a potential link with Autism Spectrum Disorder, Cheng Cheng

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Correlated Variability and Adaptation in Orbitofrontal Cortex during Economic Choice, Katherine E. Conen

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Host Determinants of Protection and Pathogenesis during Chikungunya Virus Infection, Lindsey Elaine Cook

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The Role of Membrane Excitability in Insulin Regulation, Christopher Howard Emfinger

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Mechanistic characterization of resistome and microbiome dynamics across diverse microbial habitats, Andrew John Gasparrini

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Microbiota-Directed Therapeutic Foods for the Treatment of Childhood Undernutrition, Jeanette Lynn Gehrig

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New Insights into RAF Dimerization and Its Role in MAPK Signaling, Elizabeth Germino

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The Mechanism of Hyper Daptomycin Resistance in Corynebacterium striatum and Daptomycinճ Mechanism of Action, Nicholas Kevork Goldner

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Insights into the In Vivo Role of Ifi35 in Promoting H5N1 Influenza and Neurotropic Vesicular Stomatitis Virus Disease, Anshu Priyanthi Gounder

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Batf3 Maintains Autoactivation of Irf8 for Commitment of a CD8α+ Conventional Dendritic Cell Progenitor, Gary Grajales-Reyes

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Fast Objective Coupled Planar Illumination Microscopy, Cody Jonathan Greer

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A Gnotobiotic Mouse Model of the Effects of Purified Food-Grade Plant Fibers on Microbial Community and Host Metabolism, Nathan Han

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The Role of Actr10 in Nervous System Development and Disease, Amy Herbert

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Plant Metabolic Pathways and Regulatory Networks for Aromatic Amino Acids and Hormones, Cynthia Holland

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Defining Motor Neuron-Enriched microRNAs Reveals Novel Biomarkers and Genetic Causes of Motor Neuron Disease and Uncovers New Mechanisms of Glial Dysfunction in ALS, Mariah Lawler Hoye

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Multi-omics Portraits of Cancer, Kuan-Lin Huang

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Modeling the Bioactivation and Subsequent Reactivity of Drugs, Tyler Brian Hughes

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Sequence analysis methods for the design of cancer vaccines that target tumor-specific mutant antigens (neoantigens), Jasreet Hundal

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Identification of Bhlhe40 and Irg1 as essential regulators of the inflammatory response to Mycobacterium tuberculosis, Jeremy Peter Huynh

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The splice is not right: splice-site-creating mutations in cancer genomes, Reyka Glencora Jayasinghe

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Marburg Virus is Not Ebola Virus: Biochemical and Structural Insights into Mechanisms of Immune Evasion, Britney Johnson

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The Role of Nicotinamide Mononucleotide and NAMPT-Mediated NAD+ Biosynthesis in the Regulation of Age-Related Cognitive Dysfunction, Sean Johnson

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The Role of Fibrillin-1 in Eye Development and Disease, Wendell Brooks Jones

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A high-content screen identifies HSP90 as a component of axon injury signaling, Scott Karney-Grobe

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Mitochondrial Proteostasis and Hypoxic Injury, Daniel Martin Kaufman

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Tau Prion Strains Induce Distinct Pathological Phenotypes In Vivo, Sarah Kaufman

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Integrated Epigenomic Studies of Acute Myeloid Leukemia (AML), Shamika Ketkar

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The Role of H2afy in Normal and Malignant Hematopoiesis, Sanghyun Kim

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Grammar and Variation: Understanding How cis-Regulatory Information is Encoded in Mammalian Genomes, Dana Michele King

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Discerning Drivers of Cancer: Computational Approaches to Somatic Exome Sequencing Data, Runjun Kumar

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Viral MHC Class I Evasion Affects Anti-viral T Cell Development and Responses, Elvin James Lauron

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The Ugly Sequestosome1:the role of p62/SQSTM1 in autophagy and multisystem proteinopathy, Eugene Lee

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Lysyl Oxidase Mutations in Thoracic Aortic Aneurysm and Dissection, Vivian Lee

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Loss of TREM2-dependent microgliosis in mouse models of amyloid-beta and tau pathologies reveal juxtaposed roles for reactive microglia in Alzheimerճ disease, Cheryl Elizabeth Grace Leyns

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Neural Mechanisms of Drosophila Circadian Rhythms, Xitong Liang

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Genetic Basis of Thermal Divergence in Saccharomyces species, Xueying C. Li

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Kdm6b is Required for Self-Renewal of Normal and Leukemic Mouse Stem Cells Under Proliferative Stress, Cates Mallaney

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Glucose Transporters in Hepatic Fasting Metabolism: Implications for Cardiometabolic Disease, Allyson Leigh Mayer

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Defining Neuronal Identity Using MicroRNA-Mediated Reprogramming, Matthew James Mccoy

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Tumors Interrupt IRF8-Mediated Dendritic Cell Development to Overcome Immune Surveillance, Melissa Ann Meyer

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Targeting the Microenvironment: Approaches for Reducing Breast Cancer Metastases and Chemotherapy-induced Bone Loss, Bhavna Murali

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Sex Differences in Uropathogenic Escherichia coli Urinary Tract Infection, Patrick David Olson

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Ushering CUP Pilus Assembly: Dissecting the Mechanics of a Bacterial Nanomachine, Natalie Saranga Omattage

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Regulation of Local Translation in Neuronal Processes of Specific Cell Types, Rebecca Ouwenga

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Methods to Record Transcription Factor Binding and Enhancer Activity throughout Cellular Differentiation, Zongtai Qi

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Characterization of the CELF6 RNA Binding Protein: Effects on Mouse Vocal Behavior and Biochemical Function, Michael A. Rieger

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Innate Lymphoid Cells: Transcriptional Profiles and Cytokine Developmental Requirements, Michelle Lauren Robinette

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Bone-Induced Expression of Tumoral Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases, Michael H. Ross

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Deciphering mechanisms governing the development of the rod epigenome, Philip Andrew Ruzycki

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Local Translation in Peripheral Astrocyte Processes, Kristina Sakers

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Forward and Reverse Genetic Approaches to Understanding Myelination, Nicholas Enrique Sanchez

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Breath biomarkers and an expanded role for isoprenoids in Plasmodium falciparum, Chad Louis Schaber

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Regulation of Epithelial Proliferation and Migration by Apical-Basal Polarity Proteins, Gregory Vincent Schimizzi

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Smooth as SILK: Translating Discoveries to New Therapies in Amyotrophic Lateral Sclerosis, Wade Self

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Protein Structure-Guided Approaches to Identify Functional Mutations in Cancer, Sohini Sengupta

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Tau monomer encodes Strains, Apurwa Sharma

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Novel Approaches to Studying the Effects of Cis-Regulatory Variants in the Central Nervous System, Susan Shen

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The Role of Apolipoprotein E in Regulating Tau Pathogenesis and Neurodegeneration in a Tauopathy Mouse Model, Yang Shi

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Understanding Stroke in the Connected Human Brain, Joshua Sarfaty Siegel

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Roles of ESCRT machinery in endosomal repair and recycling, Michal Leszek Skowyra

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Circadian Regulation of Temozolomide Sensitivity in Glioblastoma, Emily A. Slat

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The Role of NFκB in the Pathogenesis of Myeloproliferative Neoplasms, Steven C. Snyder

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Characterizing the Role of the T Cell Receptor Repertoire in T Cell Development and Function, Benjamin David Solomon