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Theses/Dissertations from 2024

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Rapid Unleashing Macrophage Efferocytic Capacity by Transcriptional Pause Release, Turan Tufan

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Technology Development of High-resolution Single-cell Lineage Tracing for Cell Reprogramming Systems, Sadie VanHorn

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Microbial Community Composition and Assembly in Diverse Environmental Systems, Rhiannon Celeste Vargas

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Development and Application of a Computational Pipeline for Genealogy-Based Trait Association, Xinxin Wang

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Novel bioinformatics tools for biomarker discovery in prostate cancer, Jace Webster

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Identification and Characterization of UBE3A Gain of Function Variants as a Driver of Neurodevelopmental Disease, Kellan Phoebe Weston

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Integrating DNA Methylation and 3D-genome Architecture to Identify Functional Regulatory Sequences in IDH-mutant AML, Elisabeth Wilson

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Functions of cDC1 in Mediating CD4+ Help for CD8+ T cells, Renee Wu

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Sleep Restores an Optimal Computational Regime in Cortical Networks, Yifan Xu

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Recording Transcription Factor FoxA1 and Hnf4a Binding at Single-Cell Resolution During iEP Direct Reprogramming, Xue Yang

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Neuroepigenetic Mechanisms of Brain Development: From Technology to Biological Insights, Allen Yen

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Lineage tracing of twins and families using massively parallel sequencing, Christopher Jongsoo Yoon

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Functional genomics approaches to understanding the impact of common and rare risk variants on microglia function in neurodegenerative diseases, Shih-Feng You

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Mechanisms of Electrical Substrate Reprogramming after Cardiac Radiotherapy, David Meng Zhang

Leveraging arginine catabolism to treat metabolic complications, Yiming Zhang

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Investigating the Role of Circular RNAs in Metastatic Colorectal Cancer Progression, Sidi Zhao

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Transcriptional precision in photoreceptor development and diseases - Lessons from the retinal transcription factor CRX, Yiqiao Zheng

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Dihydroceramide Desaturase Governs Endoplasmic Reticulum and Lipid Droplet Homeostasis to Promote Glial Function in the Nervous System, Yuqing Zhu

Theses/Dissertations from 2023

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Investigation of Metabolic and Molecular Pathways that Promote Gastric Parietal Cell Regeneration, Mahliyah Lenore Adkins-Threats

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Combining Simulations and Single Molecule Spectroscopy To Understand SARS-CoV-2 Nucleocapsid Protein-RNA Interactions, Jhullian Jamille Alston

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Modeling X-Linked Dystonia Parkinsonism (XDP) in Patient-Derived Medium Spiny Neurons, Shivani Aryal

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Bioinformatic tools to alleviate the annotation bottleneck within precision oncology, Erica Kay Barnell

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A Thesis on Phosphatidylserine as a Key Signaling Moiety During Adipocyte Differentiation, Brady Jeffrey Barron

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Maternal-Fetal Circadian Communication during Pregnancy, Keenan Bates

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Understanding the Spectrum of DNMT3A Mutations in Neurodevelopmental Disease, Diana Christian Beard

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Mechanisms and Consequences of Microtubule-Based Symmetry Breaking in Plant Roots, Natasha Anriel Bilkey

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Investigating the role of DciA during the cell cycle in Mycobacterium, Helen Catherine Blaine

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Antibiotic Resistance at Sequence, Population, and Global Scales, Kevin Blake

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Roles of Type I Interferon Signaling in Drug Resistant Mycobacterium tuberculosis Infection, Suhas Bobba

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Wide-field optical imaging of neurological disorders and sleep in mice, Lindsey M. Brier

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Multi-Scalar Contributions to Sex Differences in Brain Tumor Incidence and Outcome, Lauren Broestl

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Inhibiting Notch Signaling in miNs Improves Neurite Extension & Investigating the Epigenome of Alzheimer’s Disease, Kyle Foster Burbach

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Dissecting Tau Isoform Control and Modeling Tauopathies in Directly-Reprogrammed Neurons, Lucia Capano

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Identifying the Molecular Fate Logic Underlying Direct Neuronal Conversion, Kitra Cates

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UvrD1 Helicase of Mycobacterium tuberculosis that can be Activated by Multiple Unique Mechanisms, Ankita Chadda

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Investigating the relationship between smoking, genomics, and brain imaging, Yoonhoo Chang

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Investigation of the Deubiquitinating Enzyme USP7 in the Brain, Hao Chen

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The role of the neurodevelopmental disorder gene Myt1l in mammalian brain development, Jiayang Chen

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The role of the neurodevelopmental disorder gene Myt1l in mammalian brain development, Jiayang Chen

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Assessment of Cross-protective Responses to Emerging Variant Viruses, Rita Elaine Chen

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An Evolving View of Host-Microbiome Co-Development in Healthy and Undernourished Children, Robert Yuzen Chen

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Restoring the Mechanoresponsiveness of Aged Bone to Mechanical Loading, Christopher John Chermside-Scabbo

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The Microbes Within: Pathogen In-Host Adaptation and the Gut Microbiome During Persistent Colonization and Recurrent Infection, Joohee Choi

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Investigating how sterol transport affects survival of the pathogenic fungus Cryptococcus neoformans in host-like conditions, Hau Lam Choy

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IL-15 and IFN-g regulation in murine NK cells, Maria Cimpean

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On the Origin of AIDS: CARD8’s Role in Pathogenesis and Cure, Kolin Clark

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ZFP36 Family-Mediated Post-Transcriptional and Bhlhe40-Mediated Transcriptional Regulation of T Cell Responses, Melissa Erin Cook

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Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments, Matthew Alberto Cruz

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Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments, Matthew Alberto Cruz

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Single-molecule Spectroscopy of the SARS-CoV-2 Nucleocapsid Protein, Jasmine Cubuk

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Cardiovascular SARS-CoV-2 Tropism and Immunopathology, Oleksandr Dmytrenko

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A Quantum Physics-Based Force Field for Biomolecular Simulation, Roseane dos Reis Silva

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The Evolution of Transposable Elements as Cis-Regulatory Elements in Mammals, Alan Y. Du

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Genetic and Pharmacological Factors Control Aging in Caenorhabditis elegans., Brian McNally Egan

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Investigating Cassava Susceptibility to Xanthomonas Induced Bacterial Blight Using Disease Phenotyping and Genome Engineering Strategies, Kiona Rajene Elliott

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Distinct Roles for LTα3 and LTα1β2 Produced by B cells Contribute to their Multi-Faceted Impact on Ileitis, Emma Claire Erlich

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Wild Plant–Pathogen Interactions Across Gradients of Urbanization and Latitude, Quinn N. Fox

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Iterative Machine Learning of a Cis-Regulatory Grammar, Ryan Z. Friedman

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Characterization of Subcellular Functional Domains in the Vesicular Glutamate Transporter 3-Expressing Retinal Amacrine Cell using Correlative Light and Electron Microscopy, Karl Friedrichsen

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Understanding the Chemical Context of Interactions in Intrinsically Disordered Proteins, Garrett Ginell

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TRPM5's Role in Vascular Development, Megan Goeckel

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Role of Copyback Viral Genomes in Activating Cellular Stress Responses During Pneumovirus and Paramyxovirus Infection, Lavinia Jose Gonzalez Aparicio

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Circumventing Drug Resistance with Small Molecule Inhibitors of Mycobacterium tuberculosis, Gregory Alexander Harrison

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A Dynamic Duo: Investigating the Interactions between Xanthomonas citri pv. malvacearum and Pseudomonas syringae, Taylor Harris

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Function and Regulation of Virulence-Associated Siderophores in Uropathogenic Enterobacterales, James Robert Heffernan

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Function and Regulation of Virulence-Associated Siderophores in Uropathogenic Enterobacterales, James Robert Heffernan

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Biotic Interactions and the Maintenance of Biodiversity across a Tropical Elevational Gradient, David Henderson

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Investigating the Role of BHLHE40 in Host Responses to Mycobacterium tuberculosis Infection and Myeloid Cell Development, Skyler Hendrix

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The Role of Phenylacetic Acid (PAA) Catabolism in Acinetobacter Physiology, Anna Josephine Hooppaw

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Individual and Social Influences on Cigarette Smoking During Pregnancy, Alexandra Noel Houston-Ludlam

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DFCP1 Regulates Lipid Droplet Catabolism in an NTPase-Dependent Manner, Victoria Anne Ismail

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Heterogeneity of Human Tissue-Resident Lymphocytes, Natalia Jaeger

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Fluorescent-based Approaches for Quantifying Bacterial Transcription Initiation Kinetics, Drake Jensen

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Zebrafish Swim Capacity, Gait, and Posture During Innate Spinal Cord Repair, Nicholas Oliver Jensen

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Uncovering the genetic basis underlying the Pseudomonas syringae pv. tomato strain DC3000’s response to IAA and its role in regulating PtoDC3000 biology, Joshua Michael Brian Johnson

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Inter-areal Communication in Posterior Parietal Cortex Supporting Eye-hand and Bimanual Coordination, Jung Uk Kang

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Ribosomes as Sensors: How Cells Utilize the Translational Process to Monitor Cellular Conditions, Kyusik Q. Kim

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Ca2+ Dynamics and Genome Protection, Lingzhen Kong

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Identification and Characterization of Targets of Metastasis in High-Grade Serous Ovarian Cancer, Emilee Nicole Kotnik

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Identification and Characterization of Targets of Metastasis in High-Grade Serous Ovarian Cancer, Emilee Nicole Kotnik

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TAFopathies Result from Derangements in Transcriptional Regulation of Metabolism, Jamison Maxwell Leid

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Drives Blunted by Time: The Effects of Aging on Motivational Behaviors and Responses to Social Isolation in Mice, Hanyue Lei

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Construction of a Human Pangenome Reference to Improve Structural Variation Detection, Wen-Wei Liao

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Investigating Kidney Cellular Heterogeneity and Metabolism with Single-Cell Combinatorial Indexing and Spatial Multiomics, Haikuo Li

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Mechanisms of Immunopathology and Protection in Genital Herpes Simplex Virus 2 Infection, Ying Shiang Lim

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Uncovering the Determinants of Compositionally Distinct, Coexisting Biomolecular Condensates, Andrew Zijia Lin

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Histamine production by airway resident Haemophilus species induces rhinitis, Michael Lint

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Single-nuclei Resolution Kidney Profiling in Physiological And Disease Settings, Ruiyang Liu

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Evaluating the function of DNMT3A mutations associated with Acute Myeloid Leukemia and DNMT3A Overgrowth Syndrome, Yang Li

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Multi-Omics Understanding of Heterogeneity, Progression, and Therapeutic Vulnerabilities in Kidney Disease and Cancer, Yize Li

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Biophysically-informed Models of Heterogeneity in Transcription Factor Activity, Kaiser Loell

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A Mechanistic Study of ERR α/γ Agonists for Treatment of Metabolic Dysfunction in Heart Failure, Mckenna Lael Losby

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Discerning the roles of novel glycosyltransferases in the pathogenic yeast Cryptococcus neoformans, Liza Loza

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Spike-Timing-Dependent Plasticity Alters Sensory Network Connectivity, Adalee Lube

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The Sperm-Specific K+ Channel SLO3, a regulator of human fertility and new target for contraception, Maximilian Daniel Lyon

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TRANSPOSABLE ELEMENTS AS PROMOTERS IN CANCER AND NORMAL CELLS, Ju Heon Maeng

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Understanding and Combating the Spread of Antibiotic-Resistant Organisms, Bejan Mahmud

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The Role of MAVS and Interferon-Lambda in Regulating Astrovirus and Norovirus Infections, Heyde Makimaa

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The Effect of Oxytocin Receptor Genetic Variants on Oxytocin Response, Manasi Malik

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Examining Therapeutic Targets for Central Nervous System Autoimmune Disease, Sindhu Manivasagam