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Theses/Dissertations from 2022

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Tissue Resident Macrophages Drive Fibrosis During Pancreas Inflammatory Injury and Pancreatic Ductal Adenocarcinoma, John Baer

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Antigen Presentation in Central Nervous System Antitumor Immunity, Jay Aaron Bowman-Kirigin

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Characterizing complex affective processing across age and in relation to social anxiety symptoms, M. Catalina Camacho

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The role of the neurodevelopmental disorder gene Myt1l in mammalian brain development, Jiayang Chen

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Connections between Mechanosensitive Ion Channel MSL10 and ER-Plasma Membrane Contact Sites, Jennette Marie Codjoe

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Bioinformatics and cancer genomics approaches to advance precision medicine and elucidate tumor mutational landscapes, Kelsy Cotto

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Circadian Circuitry and Glioblastoma: Interactions with Behavior, Carcinogenesis, and Clinical Practice., Anna R. Damato

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Investigating the Specification and Regulation of the Human Trophoblast Lineage Using Cell Culture Models, Chen Dong

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Control of Intestinal Turnover and Cell Death through Canonical Autophagy Pathways within Mouse and Human Epithelia, John Steven Ekman

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A structural perspective on neutralizing antibodies to flaviviruses and coronaviruses, John Michael Errico

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Fructose Promotes the Growth of Tumors through Metabolite Exchange with Non-malignant Tissues, Ronald Joseph Fowle-Grider

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Regulation and Function of Integrin β3 in Bone-Metastatic Breast Cancer Cells in the Therapeutic Setting, Gregory Chandler Fox

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Functional Analysis of Recurrent Non-Coding Variants in Human Melanoma, Paula Maria Godoy

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Functional and anatomical characterization of descending periaqueductal gray (PAG) projections and their role in pain modulation, Jose Gabriel Grajales

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The Enemy Within: An Investigation of the Intracellular Bacteria in Urinary Tract Infections, Jennie Elizabeth Hazen

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The role of Fibroblast Growth Factor-9 in influenza A virus pathogenesis, Bradley Edward Hiller

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Uncovering New Mechanisms for Indole-3-butyric Acid Metabolism and Transport in Arabidopsis thaliana, Arielle Lynne Homayouni

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Understanding gene regulation with high-throughput genome-integrated reporter assays, Clarice Hong

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Understanding Individual Cells in Zebrafish Caudal Fin Regeneration (从单细胞视角理解斑马鱼尾鳍再生历程), Yiran Hou

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Analyzing the Interconnectedness of the Human Genome, Nicholas Jacobs

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Assembly and Repair of Photosystem II, Virginia M. Johnson

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Determinants of DNA Damage Responses During B Cell Development, Rachel Leigh Johnston

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Host development and microbiota influences on norovirus infection, Elizabeth Alexandra Kennedy

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DNMT3A Regulates Hematopoietic Stem Cells via DNA Methylation-Independent Functions, Won Kyun Koh

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Unraveling Population Heterogeneity using Single-Cell Analysis, Wenjun Kong

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The Impact of Nucleolar Stress on Thymocyte Development and T Cell Acute Lymphoblastic Leukemia Transformation, Joseph Ryan Krambs

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The Role of SOXE Transcription Factors in Melanoma Initiation, Eva Tulchinsky Kramer

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Contributions of Specific Retinal Circuits and Their Respective Projections to Visual Behaviors, Jenna Mackenzie Krizan

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Massively Parallel Assessment of the Functional Effects of De Novo Autism Spectrum Disorder Patient-Derived Genetic Variants in 3’ Untranslated Regions, Tomas Lagunas Jr

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Techniques for Spatial Analysis of C. elegans Anatomy and Reporter Expression, Nicolette Marie Laird

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Inferring adaptation in social microbes from experimental evolution under relaxed selection, Tyler John Larsen

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Tertiary Lymphoid Tissue in the Urinary Bladder of Aging Mice and Women, Marianne Morris Ligon

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SIK3 & Wnk signals through Fray to regulate glial K+ buffering and seizure susceptibility in Drosophila models of hyperexcitability, Lorenzo Laronn Lones

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Cell-type Specific Expression of Apolipoprotein E by Astrocytes and Microglia: Implications for the Development of Amyloid-β Pathology in Alzheimer Disease, Thomas Mahan

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Overcoming genetic heterogeneity in glioblastoma by targeting transcriptional dependencies, Tatenda Mahlokozera

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Understanding the Influence of Individual-level Sources of Pathology Variation on Neuroimaging Measures of Alzheimer Disease, Austin Andrew McCullough

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Cooperation and Conflict in the Social Amoeba Dictyostelium discoideum and its Paraburkholderia Endosymbionts, James Medina

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Insights Into the Non-Osmoregulatory Function of a Pollen-Specific Mechanosensitive Ion Channel, Kari Miller

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Genetic and Transcriptomic Aspects of Major Depressive Disorder: In Vivo Functional Assays of Risk-Associated Variation, Candidate Disease Cell Types, and Their Pharmacologic and Sex Interactions, Bernard Mulvey

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Emerging insights into a role for Topoisomerase IIB and Methyl-CpG binding protein 2 in regulating neuronal transcription, Sabin Nettles

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Disuse-Driven Plasticity in the Human Brain, Dillan James Newbold

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Extensive Behavioral Phenotyping of Williams Syndrome Locus Relevant Mouse Models to Assess Contributions of Oxytocin and Gtf2ird1, Kayla Rose Nygaard

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Analysis of Regulatory Element Variation in Autism Spectrum Disorder, Evin Mitchel Padhi

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T cell regulation of regenerative environment in acellular nerve allograft repaired peripheral nerves, Deng Pan

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The role of endoplasmic reticulum modifications in protein export in Plasmodium falciparum, Alexander Polino

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Canonical and Noncanonical Mechanisms of Resistance to Arginine Starvation in Cancer, Leonard Christopher Rogers

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Exploring the Roles of the Retinoblastoma Tumor Suppressor Complex in Chlamydomonas reinhardtii Cell Cycle Control, Sarah Rommelfanger

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Defining the role of rare genetic variants that drive risk and pathogenesis of Alzheimer’s disease, Matthew James Rosene

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Harnessing synthetic biology to create novel protein materials for applications on the nano and macro scales, Cameron Jay Sargent

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Understanding the role of involucrin in skin inflammation, Alina Schmidt

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Roles of Behavioral Novelty and Organismal Energetics in the Evolution of Extreme Encephalization, Erika Laurie Schumacher

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The Bidirectional Relationship between the Circadian Clock and Alzheimer’s disease, Patrick Sheehan

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Molecular Characterization of Integrase-RNA Interactions and Their Role in the Replication of HIV-1 and Other Retroviruses, Christian Shema Mugisha

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Using Proteomics to Discover New Connections in the Arabidopsis Circadian Clock, Maria Lynn Sorkin

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Sex Differences in Cancer Metabolism Contribute to Sex-Specific Treatment Responses, Jasmin Inge Sponagel

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Genome-wide and Targeted Screening Methods Reveal Host Antiviral Mechanisms to Limit Norovirus Infection, Meagan E. Sullender

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A Universal Mechanism of G Protein Inhibition, Tyson Daniel Todd

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Candida Species and Bacterial Strains in the Vaginal Microbiome, Brett Tortelli

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Dysregulation of Gene Expression in Non-photosensitive Trichothiodystrophy, Brittany Townley

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Mechanisms Regulating Photoreceptor Subtype Specification and Chromophore Utilization in Zebrafish, Leo Volkov

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Characterizing the role of interferons in host-microbe interactions in disseminated murine norovirus infection and steady-state hematopoiesis, Forrest Walker

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Mechanisms for High Light Tolerance in a Fast-Growing Cyanobacterium, Patricia Walker

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Role of Circadian Rhythm and Clock Regulator REV-ERBa in Group 3 Innate Lymphoid Cells, Qianli Wang

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Combining computer simulations and deep learning to understand and predict protein structural dynamics, Michael D. Ward

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Characterizing Human Gut Bacterial TIR Domains In Vitro, in Gnotobiotic Mice and Malnourished Children, James Stephen Weagley

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Generation, Characterization, and Treatment of Functional Zebrafish Models for Musculoskeletal Disorders, Julia Nicole Whittle

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Multi-Omics Investigation of Tumor Heterogeneity, Oncogenic Signaling, and Treatment Response in Human Cancers, Yige Wu

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The Maintenance of CD4 and CD8 T Cell Response to Persistent Antigens, Yu Xia

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Single-Cell Massively Parallel Reporter Assays, Siqi Zhao

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Characterization of Large-Scale Functional Network Organization in the Human Hippocampus, Annie Zheng

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VCP: A Gatekeeper for Intracellular Proteopathic Seeding, Jiang Zhu

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Macrophage Proliferation Machinery Drives Immunosuppression and PDAC Progression (巨噬细胞增值机制抑制肿瘤免疫促进胰腺癌发展), Chong Zuo

Theses/Dissertations from 2021

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Functional and therapeutic insights into Wolfram syndrome pathophysiology, Damien C. Abreu

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Human PLCG2 Haploinsufficiency Results in a Novel Immunodeficiency, Joshua Brandon Alinger

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A Study on the Hormonal Regulation and Novel Role of Na+ Leak Channel, Non-Selective (NALCN) in Human Myometrial Smooth Muscle Cells, Chinwendu Amazu

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Transcriptional Control of Dendritic Cell Function and Development, David Alexander Anderson Iii

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Genetics of Pediatric Musculoskeletal Disorders, Lilian Antunes

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Dedicated Interneuronal Microcircuits Regulated by Behavioral State, Moises William Arriaga

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Homeostatic T Cell Receptor Interactions with Self-Peptide Tune CD4+ T Cell Function, Juliet Marie Bartleson

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The Role of Soil Microbes in Improving Tallgrass Prairie Restoration and Rare Plant Reintroduction, Rachel Ellen Becknell

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Defining the epigenetic and transcriptional regulatory mechanisms by which hRSV NS1 alters host transcriptional response, Nina Rose Beri

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Potentiation of TMEM16A Currents by CLCA1 in Cystic Fibrosis Airway, Kayla Berry

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Understand and predict microbiome and resistome dynamics in response to perturbations across diverse populations and environments, Manish Boolchandani

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The evolutionary history of Camelina Crantz (Brassicaceae) and domestication of the biofuel crop, C. sativa (L.) Crantz, Jordan Brock

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Phenotyping and Preclinical Meta-Analysis of Behavioral Outcomes from Complete Freund’s Adjuvant-Induced Inflammatory Pain in the Rodent Hind-paw, Dominika J. Burek

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Association of Structural Variation (SV) with Cardiometabolic Traits in Finns, Lei Chen

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RhoA Mediated Juxtacrine Regulation of Glucagon Secretion, Yong Hee Chung

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Understanding the Roles of DNA Methylation and MeCP2 in Neuronal Enhancer Control, Adam Clemens

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Dissecting the Molecular Mechanism of Familial Cardiomyopathies, Sarah Ruth Clippinger Schulte

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Functional Interrogation of JAK2 and ASXL1 Mutations in Myeloproliferative Neoplasms, Taylor Brost Collins

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Deep Multi-omics Investigations Elucidate Novel Oncogenesis Paradigms, Therapeutic Targets, and Mechanisms of Treatment Resistance in Cancer, Daniel Cui Zhou

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Modeling Small Molecule Metabolism in Human Liver Microsome to Better Predict Toxicity Risk, Na Le Dang

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Surveillance and dynamics of bacteria and resistance genes in humans and hospitals, Alaric Wences D'Souza

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Polygenic and Transcriptomic Studies in Neurodegeneration: Towards More Precise Medicine., Umber Dube

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The Effects of Molecular Chaperone Modulation on Protein Folding, Prion Formation, and Prion Propagation in Saccharomyces cerevisiae, Leeran Blythe Dublin Ryan

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Examining Early Interactions between Innate Airway Resident Immune Cells and Mtb-specific Factors during Pulmonary Infection with Mycobacterium tuberculosis, Micah D. Dunlap

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C. elegans Response to Cadmium Toxicity, Brian James Earley

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Investigating the Integration-Independent Role of HIV-1 IN in the Viral Life Cycle, Jennifer Elliott

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Protein Synthesis Adaptation to the AU-Rich Transcriptome of Plasmodium falciparum, Jessey Lee Erath

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Understanding Immune Responses with Single-Cell RNA Sequencing and CyTOF Across Different Diseases and Model Organisms, Ekaterina Esaulova