ORCID
https://orcid.org/0000-0002-9612-7764
Date of Award
2-25-2024
Degree Name
Doctor of Philosophy (PhD)
Degree Type
Dissertation
Abstract
Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is a poorly understood, putative extracellular matrix protein. Several human traits and diseases are associated with SVEP1, including coronary artery disease, hypertension, type 2 diabetes, glaucoma, dementia, longevity, and platelet reactivity. This dissertation establishes a causal link between SVEP1 and human disease using Mendelian randomization and mouse models. It also provides insights into the disease mechanisms of the protein, including a novel interaction between SVEP1 and the orphan receptor Platelet endothelial aggregation receptor 1. The relevance of this interaction to platelet biology and its potential role in cardiometabolic disease is discussed. The viability of inhibiting SVEP1 to treat or prevent disease is also evaluated.
Language
English (en)
Chair and Committee
Nathan O Stitziel
Committee Members
Carmen M Halabi, Robert P Mecham, Joel D Schilling, Amber N Stratman
Recommended Citation
Elenbaas, Jared S., "Characterizing the Causal Role of SVEP1 in Human Disease" (2024). Arts & Sciences Electronic Theses and Dissertations. 3233.
https://openscholarship.wustl.edu/art_sci_etds/3233