Abstract

Hematopoiesis, the formation of blood and immune cells from stem and progenitor cells, is a central biological process that alters in response to the organismal state. Many cytokines that accompany diseases have an impact on the rate, cellular output, and underlying mechanisms of hematopoiesis. Deepening our understanding of the alterations to hematopoiesis that occur with disease may offer therapeutics that normalize hematopoiesis and promote health. One component of hematopoiesis that is often overlooked are the non-hematopoietic cells of the stem cell niche that have crucial roles in affecting the parameters of hematopoiesis. While progress in understanding the hematopoietic stem cell niche during homeostasis has been made, how niche interactions change during pathologic conditions is less well understood. A central focus of my graduate studies has been to illuminate the interaction between pathological states, in particular solid tumors, and the hematopoietic niche.

Committee Chair

Kyunghee Choi

Degree

Doctor of Philosophy (PhD)

Author's Department

Biology & Biomedical Sciences (Immunology)

Author's School

Graduate School of Arts and Sciences

Document Type

Dissertation

Date of Award

4-3-2024

Language

English (en)

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