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Theses/Dissertations from 2023

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Zebrafish Swim Capacity, Gait, and Posture During Innate Spinal Cord Repair, Nicholas Oliver Jensen

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Uncovering the genetic basis underlying the Pseudomonas syringae pv. tomato strain DC3000’s response to IAA and its role in regulating PtoDC3000 biology, Joshua Michael Brian Johnson

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Inter-areal Communication in Posterior Parietal Cortex Supporting Eye-hand and Bimanual Coordination, Jung Uk Kang

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Ribosomes as Sensors: How Cells Utilize the Translational Process to Monitor Cellular Conditions, Kyusik Q. Kim

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Ca2+ Dynamics and Genome Protection, Lingzhen Kong

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Identification and Characterization of Targets of Metastasis in High-Grade Serous Ovarian Cancer, Emilee Nicole Kotnik

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Identification and Characterization of Targets of Metastasis in High-Grade Serous Ovarian Cancer, Emilee Nicole Kotnik

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TAFopathies Result from Derangements in Transcriptional Regulation of Metabolism, Jamison Maxwell Leid

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Drives Blunted by Time: The Effects of Aging on Motivational Behaviors and Responses to Social Isolation in Mice, Hanyue Lei

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Construction of a Human Pangenome Reference to Improve Structural Variation Detection, Wen-Wei Liao

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Investigating Kidney Cellular Heterogeneity and Metabolism with Single-Cell Combinatorial Indexing and Spatial Multiomics, Haikuo Li

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Mechanisms of Immunopathology and Protection in Genital Herpes Simplex Virus 2 Infection, Ying Shiang Lim

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Uncovering the Determinants of Compositionally Distinct, Coexisting Biomolecular Condensates, Andrew Zijia Lin

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Histamine production by airway resident Haemophilus species induces rhinitis, Michael Lint

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Single-nuclei Resolution Kidney Profiling in Physiological And Disease Settings, Ruiyang Liu

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Evaluating the function of DNMT3A mutations associated with Acute Myeloid Leukemia and DNMT3A Overgrowth Syndrome, Yang Li

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Multi-Omics Understanding of Heterogeneity, Progression, and Therapeutic Vulnerabilities in Kidney Disease and Cancer, Yize Li

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Biophysically-informed Models of Heterogeneity in Transcription Factor Activity, Kaiser Loell

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A Mechanistic Study of ERR α/γ Agonists for Treatment of Metabolic Dysfunction in Heart Failure, Mckenna Lael Losby

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Discerning the roles of novel glycosyltransferases in the pathogenic yeast Cryptococcus neoformans, Liza Loza

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Spike-Timing-Dependent Plasticity Alters Sensory Network Connectivity, Adalee Lube

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The Sperm-Specific K+ Channel SLO3, a regulator of human fertility and new target for contraception, Maximilian Daniel Lyon

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TRANSPOSABLE ELEMENTS AS PROMOTERS IN CANCER AND NORMAL CELLS, Ju Heon Maeng

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Understanding and Combating the Spread of Antibiotic-Resistant Organisms, Bejan Mahmud

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The Role of MAVS and Interferon-Lambda in Regulating Astrovirus and Norovirus Infections, Heyde Makimaa

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The Effect of Oxytocin Receptor Genetic Variants on Oxytocin Response, Manasi Malik

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Examining Therapeutic Targets for Central Nervous System Autoimmune Disease, Sindhu Manivasagam

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Shining a Light through a Multiomic Lens on Germline Variants: Patterns and Functional Implications Across Cancer Types, Fernanda Martins Rodrigues

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Function of Deubiquitinase MYSM1 in Attenuation of DNA Damage Responses, Brendan Mathias

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Understanding Thermotolerance in Photosynthetic Cells: From Green Algae to Land Plants, Erin Marie Mattoon

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tRNA Methyltransferases Mediate Acinetobacter baumannii Pathobiology, Jenna McGuffey

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Circadian Protein BMAL1 Regulates Astrocyte Activation and Protein Degradation in Health and Disease, Celia Augusta Mckee

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Evaluating the Utility of S100A8/A9 as a Non-Invasive Biomarker, Leah Mellett

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Mass Spectrometry-Based Discovery of Tumor Antigens for Cancer Immunotherapy, Wei Meng

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Investigating the Effects of Opioid Exposure and Withdrawal on Endogenous Opioid Peptide Systems, Neuroimmune Interactions, and Striatal Neuron Activity, Marwa Mikati

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The role of Gardnerella in bacterial vaginosis and facilitating colonization by Neisseria gonorrhoeae, Sydney Rose Morrill

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Development of Myelin in Wolfram Syndrome, Olga Reine Neyman

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The Painful Problem: Improving Preclinical Pain Assessment to Probe Locus Coeruleus Noradrenergic Adaptations During Chronic Pain, Makenzie Norris

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Roles of the Transcription Factors Bcl6, IRF2, and Notch2 in Myeloid Development, Kevin William O'connor

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Dynamics of Epithelial Differentiation Following Intestinal Villus Injury, Takahiro Erick Ohara

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Following the Paper Trail: An Ethnoecology of Hand Papermaking Traditions, James Ojascastro

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Effect of Age at Injury on Neuroinflammatory Response, Microstructural Outcomes, and Function Following Traumatic Brain Injury, Sydney J. Oswalt Reitz

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The Regulation of Innate Lymphoid Cells, Vincent Peng

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An Investigation of Second-Site Non-Complementation among Motile Cilia Genes in Chlamydomonas reinhardtii, Gervette M. Penny

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An Investigation of Second-Site Non-Complementation among Motile Cilia Genes in Chlamydomonas reinhardtii, Gervette M. Penny

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Examining the Role of Microglia in Diabetic Retinopathy: Phenotypes, Mechanisms, and Therapies, Charles W. Pfeifer

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Characterizing the Significance of polyA tracks in Gene Regulation and Disease, Geralle Norlene Powell-Rodgers

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Sources and consequences of cell-to-cell variability in gene expression, Avinash Ramu

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Unraveling the Molecular Basis of Zinc Cluster Transcription Factor Specificity: A Comprehensive Study of Half-Site Promoter Binding Interactions and their Role in Gene Expression Regulation, Pamela Samantha Recio

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Investigating Novel Neoantigen Sources for Personalized Cancer Vaccines, Megan Richters

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Identifying Molecular Targets of ADAR1 Dependency in Breast Cancer, Sua Ryu

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Influence of Environmental Gradients on Genomic Variation in Pediatric Commensals and Pathogens, Sanjam Sawhney

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Cancer Immunogenomics Approaches to Characterizing and Treating Malignant Brain Tumors, Maximilian Oswald Schaettler

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Context Dependence, Cheating, and Long-term Conflict in Social Interactions, Trey Scott

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Development of computational and experimental approaches for RNA virus serology, Brittany Kaye Smith

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Automated Processing of Metabolomics Data for Population-scale Studies, Ethan Stancliffe

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Apolipoprotein E Adopts an Antiparallel Dimer in Discoidal Lipoproteins, Michael Ray Strickland

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A Human STAT3 GOF Variant Alters T Cell Function to Drive Skin Inflammation, Kelsey Adele Toth

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Mapping Brain Development and Decoding Brain Activity with Diffuse Optical Tomography, Kalyan Tripathy

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A Thesis on the Human Genetic Basis of Severe Pneumococcal Infection in Papua New Guinea, Emma Catherine Walker

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Charting the Landscape of Ventral Stream Neural Code on Generative Image Manifolds, Binxu Wang

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The Role of NS1 in Flavivirus Immunity and Pathogenesis, Alex W. Wessel

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The influence of the gut microbiota on asthma in school-aged children and adults, Naomi Grace Wilson

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Immunity to Emerging RNA Viruses, Emma Winkler

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T-bet and Eomes Are Required for Mature NK Cell Homeostasis and Function, Pamela Wong

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Improving Neoantigen Prioritization Methods for Personalized Cancer Vaccines, Huiming Xia

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TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade, Yan Xiong

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Investigating Disease Progression and Therapeutic Targets in Multiple Myeloma Using Single-cell Technologies, Lijun Yao

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Physiological Heterogeneity and Pain-Associated Plasticity in Human Sensory Neurons, Jiwon Yi

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Structural Basis of Gating in MSL Channels, Jingying Zhang

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Mechanisms of transcription regulation by CarD in Mycobacterium, Dennis Xiaoqian Zhu

Theses/Dissertations from 2022

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The Effects of NMDA Antagonism on Neuronal Activity and Neurovascular Coupling in Non-Human Primate Cortex, Benjamin Thomas Acland

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System shock: Using -omics data to characterize biological remodeling in the microbiome, resistome, and transcriptome of bacteria, Winston Eugene Anthony

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The Relationship Between Inflammation, Metabolism and Oxidative Stress in Chondrocytes: Drivers of Osteoarthritic Changes, Manoj Arra

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Tissue Resident Macrophages Drive Fibrosis During Pancreas Inflammatory Injury and Pancreatic Ductal Adenocarcinoma, John Baer

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Antigen Presentation in Central Nervous System Antitumor Immunity, Jay Aaron Bowman-Kirigin

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Characterizing complex affective processing across age and in relation to social anxiety symptoms, M. Catalina Camacho

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The role of the neurodevelopmental disorder gene Myt1l in mammalian brain development, Jiayang Chen

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Connections between Mechanosensitive Ion Channel MSL10 and ER-Plasma Membrane Contact Sites, Jennette Marie Codjoe

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Bioinformatics and cancer genomics approaches to advance precision medicine and elucidate tumor mutational landscapes, Kelsy Cotto

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Circadian Circuitry and Glioblastoma: Interactions with Behavior, Carcinogenesis, and Clinical Practice., Anna R. Damato

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Investigating the Specification and Regulation of the Human Trophoblast Lineage Using Cell Culture Models, Chen Dong

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Control of Intestinal Turnover and Cell Death through Canonical Autophagy Pathways within Mouse and Human Epithelia, John Steven Ekman

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A structural perspective on neutralizing antibodies to flaviviruses and coronaviruses, John Michael Errico

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Fructose Promotes the Growth of Tumors through Metabolite Exchange with Non-malignant Tissues, Ronald Joseph Fowle-Grider

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Regulation and Function of Integrin β3 in Bone-Metastatic Breast Cancer Cells in the Therapeutic Setting, Gregory Chandler Fox

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Functional Analysis of Recurrent Non-Coding Variants in Human Melanoma, Paula Maria Godoy

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Functional and anatomical characterization of descending periaqueductal gray (PAG) projections and their role in pain modulation, Jose Gabriel Grajales

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The Enemy Within: An Investigation of the Intracellular Bacteria in Urinary Tract Infections, Jennie Elizabeth Hazen

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The role of Fibroblast Growth Factor-9 in influenza A virus pathogenesis, Bradley Edward Hiller

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Uncovering New Mechanisms for Indole-3-butyric Acid Metabolism and Transport in Arabidopsis thaliana, Arielle Lynne Homayouni

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Understanding gene regulation with high-throughput genome-integrated reporter assays, Clarice Hong

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Understanding Individual Cells in Zebrafish Caudal Fin Regeneration (从单细胞视角理解斑马鱼尾鳍再生历程), Yiran Hou

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Analyzing the Interconnectedness of the Human Genome, Nicholas Jacobs

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Assembly and Repair of Photosystem II, Virginia M. Johnson

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Determinants of DNA Damage Responses During B Cell Development, Rachel Leigh Johnston

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Host development and microbiota influences on norovirus infection, Elizabeth Alexandra Kennedy

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DNMT3A Regulates Hematopoietic Stem Cells via DNA Methylation-Independent Functions, Won Kyun Koh

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Unraveling Population Heterogeneity using Single-Cell Analysis, Wenjun Kong

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The Impact of Nucleolar Stress on Thymocyte Development and T Cell Acute Lymphoblastic Leukemia Transformation, Joseph Ryan Krambs