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Theses/Dissertations from 2023

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Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments, Matthew Alberto Cruz

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Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments, Matthew Alberto Cruz

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Single-molecule Spectroscopy of the SARS-CoV-2 Nucleocapsid Protein, Jasmine Cubuk

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Cardiovascular SARS-CoV-2 Tropism and Immunopathology, Oleksandr Dmytrenko

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A Quantum Physics-Based Force Field for Biomolecular Simulation, Roseane dos Reis Silva

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The Evolution of Transposable Elements as Cis-Regulatory Elements in Mammals, Alan Y. Du

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Genetic and Pharmacological Factors Control Aging in Caenorhabditis elegans., Brian McNally Egan

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Investigating Cassava Susceptibility to Xanthomonas Induced Bacterial Blight Using Disease Phenotyping and Genome Engineering Strategies, Kiona Rajene Elliott

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Distinct Roles for LTα3 and LTα1β2 Produced by B cells Contribute to their Multi-Faceted Impact on Ileitis, Emma Claire Erlich

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Wild Plant–Pathogen Interactions Across Gradients of Urbanization and Latitude, Quinn N. Fox

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Iterative Machine Learning of a Cis-Regulatory Grammar, Ryan Z. Friedman

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Characterization of Subcellular Functional Domains in the Vesicular Glutamate Transporter 3-Expressing Retinal Amacrine Cell using Correlative Light and Electron Microscopy, Karl Friedrichsen

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Understanding the Chemical Context of Interactions in Intrinsically Disordered Proteins, Garrett Ginell

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TRPM5's Role in Vascular Development, Megan Goeckel

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Role of Copyback Viral Genomes in Activating Cellular Stress Responses During Pneumovirus and Paramyxovirus Infection, Lavinia Jose Gonzalez Aparicio

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Circumventing Drug Resistance with Small Molecule Inhibitors of Mycobacterium tuberculosis, Gregory Alexander Harrison

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A Dynamic Duo: Investigating the Interactions between Xanthomonas citri pv. malvacearum and Pseudomonas syringae, Taylor Harris

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Function and Regulation of Virulence-Associated Siderophores in Uropathogenic Enterobacterales, James Robert Heffernan

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Function and Regulation of Virulence-Associated Siderophores in Uropathogenic Enterobacterales, James Robert Heffernan

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Biotic Interactions and the Maintenance of Biodiversity across a Tropical Elevational Gradient, David Henderson

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Investigating the Role of BHLHE40 in Host Responses to Mycobacterium tuberculosis Infection and Myeloid Cell Development, Skyler Hendrix

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The Role of Phenylacetic Acid (PAA) Catabolism in Acinetobacter Physiology, Anna Josephine Hooppaw

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Individual and Social Influences on Cigarette Smoking During Pregnancy, Alexandra Noel Houston-Ludlam

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DFCP1 Regulates Lipid Droplet Catabolism in an NTPase-Dependent Manner, Victoria Anne Ismail

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Heterogeneity of Human Tissue-Resident Lymphocytes, Natalia Jaeger

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Fluorescent-based Approaches for Quantifying Bacterial Transcription Initiation Kinetics, Drake Jensen

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Zebrafish Swim Capacity, Gait, and Posture During Innate Spinal Cord Repair, Nicholas Oliver Jensen

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Uncovering the genetic basis underlying the Pseudomonas syringae pv. tomato strain DC3000’s response to IAA and its role in regulating PtoDC3000 biology, Joshua Michael Brian Johnson

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Inter-areal Communication in Posterior Parietal Cortex Supporting Eye-hand and Bimanual Coordination, Jung Uk Kang

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Ribosomes as Sensors: How Cells Utilize the Translational Process to Monitor Cellular Conditions, Kyusik Q. Kim

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Ca2+ Dynamics and Genome Protection, Lingzhen Kong

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Identification and Characterization of Targets of Metastasis in High-Grade Serous Ovarian Cancer, Emilee Nicole Kotnik

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Identification and Characterization of Targets of Metastasis in High-Grade Serous Ovarian Cancer, Emilee Nicole Kotnik

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TAFopathies Result from Derangements in Transcriptional Regulation of Metabolism, Jamison Maxwell Leid

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Drives Blunted by Time: The Effects of Aging on Motivational Behaviors and Responses to Social Isolation in Mice, Hanyue Lei

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Construction of a Human Pangenome Reference to Improve Structural Variation Detection, Wen-Wei Liao

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Investigating Kidney Cellular Heterogeneity and Metabolism with Single-Cell Combinatorial Indexing and Spatial Multiomics, Haikuo Li

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Mechanisms of Immunopathology and Protection in Genital Herpes Simplex Virus 2 Infection, Ying Shiang Lim

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Uncovering the Determinants of Compositionally Distinct, Coexisting Biomolecular Condensates, Andrew Zijia Lin

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Histamine production by airway resident Haemophilus species induces rhinitis, Michael Lint

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Single-nuclei Resolution Kidney Profiling in Physiological And Disease Settings, Ruiyang Liu

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Evaluating the function of DNMT3A mutations associated with Acute Myeloid Leukemia and DNMT3A Overgrowth Syndrome, Yang Li

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Multi-Omics Understanding of Heterogeneity, Progression, and Therapeutic Vulnerabilities in Kidney Disease and Cancer, Yize Li

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Biophysically-informed Models of Heterogeneity in Transcription Factor Activity, Kaiser Loell

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A Mechanistic Study of ERR α/γ Agonists for Treatment of Metabolic Dysfunction in Heart Failure, Mckenna Lael Losby

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Discerning the roles of novel glycosyltransferases in the pathogenic yeast Cryptococcus neoformans, Liza Loza

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Spike-Timing-Dependent Plasticity Alters Sensory Network Connectivity, Adalee Lube

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The Sperm-Specific K+ Channel SLO3, a regulator of human fertility and new target for contraception, Maximilian Daniel Lyon

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TRANSPOSABLE ELEMENTS AS PROMOTERS IN CANCER AND NORMAL CELLS, Ju Heon Maeng

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Understanding and Combating the Spread of Antibiotic-Resistant Organisms, Bejan Mahmud

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The Role of MAVS and Interferon-Lambda in Regulating Astrovirus and Norovirus Infections, Heyde Makimaa

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The Effect of Oxytocin Receptor Genetic Variants on Oxytocin Response, Manasi Malik

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Examining Therapeutic Targets for Central Nervous System Autoimmune Disease, Sindhu Manivasagam

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Shining a Light through a Multiomic Lens on Germline Variants: Patterns and Functional Implications Across Cancer Types, Fernanda Martins Rodrigues

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Function of Deubiquitinase MYSM1 in Attenuation of DNA Damage Responses, Brendan Mathias

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Understanding Thermotolerance in Photosynthetic Cells: From Green Algae to Land Plants, Erin Marie Mattoon

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tRNA Methyltransferases Mediate Acinetobacter baumannii Pathobiology, Jenna McGuffey

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Circadian Protein BMAL1 Regulates Astrocyte Activation and Protein Degradation in Health and Disease, Celia Augusta Mckee

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Evaluating the Utility of S100A8/A9 as a Non-Invasive Biomarker, Leah Mellett

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Mass Spectrometry-Based Discovery of Tumor Antigens for Cancer Immunotherapy, Wei Meng

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Investigating the Effects of Opioid Exposure and Withdrawal on Endogenous Opioid Peptide Systems, Neuroimmune Interactions, and Striatal Neuron Activity, Marwa Mikati

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The role of Gardnerella in bacterial vaginosis and facilitating colonization by Neisseria gonorrhoeae, Sydney Rose Morrill

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Development of Myelin in Wolfram Syndrome, Olga Reine Neyman

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The Painful Problem: Improving Preclinical Pain Assessment to Probe Locus Coeruleus Noradrenergic Adaptations During Chronic Pain, Makenzie Norris

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Roles of the Transcription Factors Bcl6, IRF2, and Notch2 in Myeloid Development, Kevin William O'connor

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Dynamics of Epithelial Differentiation Following Intestinal Villus Injury, Takahiro Erick Ohara

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Following the Paper Trail: An Ethnoecology of Hand Papermaking Traditions, James Ojascastro

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Effect of Age at Injury on Neuroinflammatory Response, Microstructural Outcomes, and Function Following Traumatic Brain Injury, Sydney J. Oswalt Reitz

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The Regulation of Innate Lymphoid Cells, Vincent Peng

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An Investigation of Second-Site Non-Complementation among Motile Cilia Genes in Chlamydomonas reinhardtii, Gervette M. Penny

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An Investigation of Second-Site Non-Complementation among Motile Cilia Genes in Chlamydomonas reinhardtii, Gervette M. Penny

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Examining the Role of Microglia in Diabetic Retinopathy: Phenotypes, Mechanisms, and Therapies, Charles W. Pfeifer

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Characterizing the Significance of polyA tracks in Gene Regulation and Disease, Geralle Norlene Powell-Rodgers

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Sources and consequences of cell-to-cell variability in gene expression, Avinash Ramu

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Unraveling the Molecular Basis of Zinc Cluster Transcription Factor Specificity: A Comprehensive Study of Half-Site Promoter Binding Interactions and their Role in Gene Expression Regulation, Pamela Samantha Recio

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Investigating Novel Neoantigen Sources for Personalized Cancer Vaccines, Megan Richters

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Identifying Molecular Targets of ADAR1 Dependency in Breast Cancer, Sua Ryu

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Influence of Environmental Gradients on Genomic Variation in Pediatric Commensals and Pathogens, Sanjam Sawhney

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Cancer Immunogenomics Approaches to Characterizing and Treating Malignant Brain Tumors, Maximilian Oswald Schaettler

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Context Dependence, Cheating, and Long-term Conflict in Social Interactions, Trey Scott

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Development of computational and experimental approaches for RNA virus serology, Brittany Kaye Smith

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Automated Processing of Metabolomics Data for Population-scale Studies, Ethan Stancliffe

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Apolipoprotein E Adopts an Antiparallel Dimer in Discoidal Lipoproteins, Michael Ray Strickland

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A Human STAT3 GOF Variant Alters T Cell Function to Drive Skin Inflammation, Kelsey Adele Toth

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Mapping Brain Development and Decoding Brain Activity with Diffuse Optical Tomography, Kalyan Tripathy

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A Thesis on the Human Genetic Basis of Severe Pneumococcal Infection in Papua New Guinea, Emma Catherine Walker

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Charting the Landscape of Ventral Stream Neural Code on Generative Image Manifolds, Binxu Wang

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The Role of NS1 in Flavivirus Immunity and Pathogenesis, Alex W. Wessel

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The influence of the gut microbiota on asthma in school-aged children and adults, Naomi Grace Wilson

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Immunity to Emerging RNA Viruses, Emma Winkler

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T-bet and Eomes Are Required for Mature NK Cell Homeostasis and Function, Pamela Wong

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Improving Neoantigen Prioritization Methods for Personalized Cancer Vaccines, Huiming Xia

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TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade, Yan Xiong

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Investigating Disease Progression and Therapeutic Targets in Multiple Myeloma Using Single-cell Technologies, Lijun Yao

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Physiological Heterogeneity and Pain-Associated Plasticity in Human Sensory Neurons, Jiwon Yi

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Structural Basis of Gating in MSL Channels, Jingying Zhang

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Mechanisms of transcription regulation by CarD in Mycobacterium, Dennis Xiaoqian Zhu

Theses/Dissertations from 2022

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The Effects of NMDA Antagonism on Neuronal Activity and Neurovascular Coupling in Non-Human Primate Cortex, Benjamin Thomas Acland

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System shock: Using -omics data to characterize biological remodeling in the microbiome, resistome, and transcriptome of bacteria, Winston Eugene Anthony

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The Relationship Between Inflammation, Metabolism and Oxidative Stress in Chondrocytes: Drivers of Osteoarthritic Changes, Manoj Arra