Abstract
In 2008, the Kenneth Murphy Laboratory published the seminal discovery that BATF3 is an essential transcription factor (TF) for the development of classical dendritic cell type 1 (cDC1) (Hildner et al., 2008). Since then, two major themes of the lab have been to elucidate the genetic networks that control dendritic cell (DC) development and to define the unique functions of individual DC subsets. My dissertation aligns primarily with the former theme while also reflecting my own scientific interests. Specifically, this dissertation investigates how two developmental enhancers are controlled by a series of TFs in cell type- and stage-specific manners to regulate DC fate segregation. Together, these enhancers and TFs form molecular circuits that govern DC development.
Committee Chair
Kenneth Murphy
Committee Members
Gwendalyn Randolph; Jonathan Kipnis; Takeshi Egawa; Ting Wang
Degree
Doctor of Philosophy (PhD)
Author's Department
Biology & Biomedical Sciences (Immunology)
Document Type
Dissertation
Date of Award
4-27-2026
Language
English (en)
DOI
https://doi.org/10.7936/c9w4-s703
Recommended Citation
Ou, Feiya, "Molecular Circuits in Dendritic Cell Development" (2026). Arts & Sciences Graduate Student Theses and Dissertations. 3796.
The definitive version is available at https://doi.org/10.7936/c9w4-s703