Abstract
This study investigates the variable responses of MSCs from bone marrow versus adipose tissue under mechanical loading within alginate matrices modified with cyclic RGD (cRGD) peptides. We explored the dynamic expression of inflammation and stress-related genes and monitored nitric oxide secretion. The work described in this independent study report is ongoing and the results presented here are preliminary findings. By integrating gene expression analysis with secretion measurements, this research will investigate whether cRGD conjugation may offer protective effects against adverse environments such as injurious compression.
Document Type
Final Report
Class Name
Mechanical Engineering and Material Sciences Independent Study
Date of Submission
5-8-2024
Recommended Citation
Greenwood, Augustus, "Mechanical Loading and RGD-Conjugation: Influences on Mesenchymal Stem Cell Response" (2024). Mechanical Engineering and Materials Science Independent Study. 274.
https://openscholarship.wustl.edu/mems500/274