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Abstract
This study involves the use of silicon-based acoustofluidic platforms for organoid and bead assembly with applications in cancer research. Utilizing the unique properties of silicon, e.g., suitability for microfabrication and a high acoustic impedance, we developed microfluidic chips designed to enhance the precision and control of cell clustering processes. Through a combination of numerical simulations and experimental testing, including eigenfrequency analysis and particle manipulation experiments, this research establishes the ability to finely tune acoustic fields for the assembly of cell clusters into organoids. The study further explores the optimization of piezoelectric transducers (PZTs) to improve energy efficiency and operational stability, addressing the challenges of repeatability and temperature management in biomicrofluidic applications. The findings offer significant insight into the potential of acoustofluidic technologies to advance personalized cancer treatments and to enhance our understanding of tumor biology.
Document Type
Final Report
Class Name
Mechanical Engineering and Material Sciences Independent Study
Date of Submission
5-13-2024
Recommended Citation
Kamalidolatabadi, Aaron, "Silicon-Based Acoustofluidic Platforms for Enhanced Organoid/Bead Assembly and Cancer Research" (2024). Mechanical Engineering and Materials Science Independent Study. 261.
https://openscholarship.wustl.edu/mems500/261