Abstract
This project explores the impact of Yoda1, a Piezo1 channel activator, on the mechanical properties of mouse ascending aortas using myograph techniques. The research aims to investigate the role of Piezo1 channels in vascular mechanics by observing force responses in aortic rings subjected to different concentrations of Yoda1. Results indicate that Yoda1 induces significant force rises due to Piezo1 activation and subsequent Ca2+ influx, causing vascular contraction. Higher concentrations of Yoda1 (50μM and 250μM) produce more pronounced force responses compared to lower concentrations (10μM and 20μM) and control treatments (PBS and DMSO). However, the results also suggest further exploration of Ca2+ signaling and physiological conditions are needed to refine these findings.
Document Type
Final Report
Class Name
Mechanical Engineering and Material Sciences Independent Study
Date of Submission
5-7-2024
Recommended Citation
ZHANG, ZHUANGYU, "Investigate the Effects of Yoda1 on Piezo1 Channels of Mouse Aorta through Myograph Techniques" (2024). Mechanical Engineering and Materials Science Independent Study. 257.
https://openscholarship.wustl.edu/mems500/257