Bone metastasis in breast cancer patients is a prominent problem, with 70% of metastatic breast cancer patients having bone metastasis.[1] The resulting complications are painful and decrease patient survival rate.[1,3] This study is based on the previous lab work of Ross et al., who found that bone metastatic breast cancer cells over-express the integrin αvβ3. Through a series of in vitro experiments, this study sought to investigate the degree to which the single lipid membrane αvβ3-targeted nanoparticles could function as a less toxic and more effective treatment to bone metastatic breast cancer.

Document Type

Final Report

Author's School

McKelvey School of Engineering

Author's Department

Mechanical Engineering and Materials Science

Class Name

Mechanical Engineering and Material Sciences Independent Study

Date of Submission