Date of Award
Doctor of Philosophy (PhD)
Chair and Committee
Creation of an accurate model for the undiseased human ventricular action potential: AP) which reproduces a broad range of physiological behaviors requires extensive experimental data, of which essential elements have been unavailable. We developed and validated such a model using new experimental data from endocardium of 140 undiseased human hearts. 78 were from male: 56%). Average age was 41 with standard deviation of 12 years. New experiments include: Ca2+ versus voltage dependent inactivation of L-type Ca2+ current; kinetics for the transient outward, rapid delayed rectifier, Na+/Ca2+ exchange, and inward rectifier currents; AP recordings at all physiological cycle lengths; steady state rate dependence and restitution of AP duration. The model was used to investigate the "silent" Long-QT mutation Q357R in KCNQ1.
O'Hara, Thomas, "Simulation Of The Undiseased Human Cardiac Ventricular Action Potential: Model Formulation, Experimental Validation And Application" (2011). All Theses and Dissertations (ETDs). 873.