Author's School

School of Engineering & Applied Science

Author's Department/Program

Biomedical Engineering


English (en)

Date of Award


Degree Type


Degree Name

Doctor of Philosophy (PhD)

Chair and Committee

Yoram Rudy


Creation of an accurate model for the undiseased human ventricular action potential: AP) which reproduces a broad range of physiological behaviors requires extensive experimental data, of which essential elements have been unavailable. We developed and validated such a model using new experimental data from endocardium of 140 undiseased human hearts. 78 were from male: 56%). Average age was 41 with standard deviation of 12 years. New experiments include: Ca2+ versus voltage dependent inactivation of L-type Ca2+ current; kinetics for the transient outward, rapid delayed rectifier, Na+/Ca2+ exchange, and inward rectifier currents; AP recordings at all physiological cycle lengths; steady state rate dependence and restitution of AP duration. The model was used to investigate the "silent" Long-QT mutation Q357R in KCNQ1.


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