Author's School

Graduate School of Arts & Sciences

Author's Department/Program

Chemistry

Language

English (en)

Date of Award

1-1-2011

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Chair and Committee

Joseph Ackerman

Abstract

Perfusion-sensitive MR methods are increasingly utilized in preclinical and clinical MR research studies with the promise of providing quantitative estimates of parameters that describe in vivo microvasculature. One of these techniques, dynamic contrast enhanced: DCE) MRI, has found particularly common use in oncology for the detection, staging, and monitoring of highly vascularized tumors. DCE-MRI has been qualitatively validated by various studies that show a high correlation between modeled parameters from DCE and histologically measured microvascular density: MVD). However, in the absence of a matching "gold-standard" technique, DCE-MRI has not yet been quantitatively validated: i.e., the accuracy of the estimated parameters is unknown). Partly because of this inability to determine the accuracy of the measured parameters, there remains debate in the literature about which DCE signal model(s) best reflect(s) experimental data. In order to address these scientific challenges, realistic DCE tissue phantoms have been constructed. These phantoms implement semi-permeable hollow fibers, found commonly in commercial hemodialysis cartridges, to simulate "leaky" vasculature. Their design and construction are cataloged in this thesis. In addition, the phantoms have been experimentally characterized. In conjunction with these experiments, an interesting example of diffusion driven longitudinal relaxation was observed and is described herein. Lastly, the permeability of the fiber wall with respect to Gd-based contrast agents has been measured independently and compared with values derived from a mock-DCE experiment performed on the phantoms. In general, the results of these experiments support current DCE-MRI methods.

Comments

Permanent URL: http://dx.doi.org/10.7936/K70R9MD2

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