System integration and performance study of MicroInsert-II PET system

Abstract

PET provides an in vivo molecular and functional imaging capability that could be valuable for studying various disease using animal models through small-animal imaging. Previously, Micro Insert, a high-resolution small-animal PET system that can improve the image resolution of a commercial PET scanner was developed and validated. This work studies the system integration of MicroInsert-II, a second generation PET insert system, as both a standalone PET and a virtual-pinhole PET. The initial performance of the system was evaluated based on the detect or energy resolution, system timing resolution and crystal efficiency, and line source imaging experiment. The results indicate a 14.5 ± 1.1% FWHM detector block energy resolution, 1.94 ± 0.38 ns detector timing resolution from the standalone mode, and ~2 ns cross-ring timing resolution and uniform cross-ring crystal efficiencies in the scanner-insert mode. The reconstructed line source image also indicates the good working status of the system. Our system exhibits the potential to provide a sub-millimeter resolution imaging capability both as a standalone PET system and a virtual-pinhole PET insert.

Committee Chair

Yuan-Chuan Tai

Committee Members

Mark Anastasio

Comments

Permanent URL: https://doi.org/10.7936/K7TQ5ZQT

Degree

Master of Science (MS)

Author's Department

Biomedical Engineering

Author's School

McKelvey School of Engineering

Document Type

Thesis

Date of Award

Summer 8-13-2015

Language

English (en)

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