Abstract
Neutrophil extracellular traps involve the rapid translocation of DNA to the outside of the cell under certain stimuli. This structure forms a fibrous network that is able to limit the spread of pathogens and to kill microorganisms. It has also been shown to be present in various pathological processes such as inflammation, autoimmune diseases, and cancer metastasis. Currently, the formation process of NETs in vivo is being extensively studied. However noninvasive detection and quantitation has yet to be achieved. A class of PET tracers are described here that consists of a DNA dye as the backbone that is labeled with an emerging positron emitting isotope of research and clinical interest, 44Sc. We describe the synthesis and radiolabeling of several NET probes and their in vivo pharmacokinetics.
Committee Chair
Daniel L.J. Thorek, PhD, Radiology, Biomedical Engineering
Committee Members
Hanwen Zhang, PhD, Radiology Buck Rogers, PhD, Radiation Oncology Michael Nickels, PhD, Radiology
Degree
Master of Science (MS)
Author's Department
Biomedical Engineering
Document Type
Thesis
Date of Award
Spring 5-2023
Language
English (en)
DOI
https://doi.org/10.7936/q9sw-rg65
Author's ORCID
https://orcid.org/0000-0003-1313-1731
Recommended Citation
Li, Zhiyao, "Synthesis, Radiolabeling and Evaluation of a suite of Tracers with 44Sc for Detecting Extracellular DNA" (2023). McKelvey School of Engineering Theses & Dissertations. 829.
The definitive version is available at https://doi.org/10.7936/q9sw-rg65
Included in
Bioimaging and Biomedical Optics Commons, Organic Chemistry Commons, Radiochemistry Commons, Radiology Commons