ORCID
https://orcid.org/0000-0003-3669-4297
Date of Award
Winter 12-15-2016
Degree Name
Doctor of Philosophy (PhD)
Degree Type
Dissertation
Abstract
Photoacoustic imaging holds great clinical promise because it achieves high-resolution tomographic imaging at depths. Moreover, its strong spectroscopic imaging capability provides a wealth of molecular and functional information based on. Still, despite recent advances, existing photoacoustic systems cannot be readily applied in the clinical environment. This dissertation aims to push the frontier of clinical photoacoustic imaging from both technological and applicational perspectives.
The first part of this dissertation describes the development of photoacoustic endoscopy (PAE) systems for imaging human Barrett's esophagus and studying preterm birth. We have developed optical resolution-PAE, which significantly improved lateral resolutions, laparoscopic-PAE, which can guide minimally-invasive surgeries, and catheter-based-PAE, which opens up new opportunities to image the human esophagus. For each system, we tested and optimized the imaging performance in phantom and animal experiments, and then validated them in humans.
The second part of the dissertation describes advanced photoacoustic imaging aided by contrast agents. Specifically, gold nanoparticles were used to quantify biological diffusion photoacoustically. In addition, ion nanosensors were applied for continuously monitoring therapeutic lithium concentration in deep tissue in vivo.
Language
English (en)
Chair
Lihong V. Wang
Committee Members
Samuel Achilefu, Mark A. Anastasio, James G. Miller, Lan Yang
Comments
Permanent URL: https://doi.org/10.7936/K7TM78J1