Date of Award
Spring 5-8-2024
Degree Name
Master of Science (MS)
Degree Type
Thesis
Abstract
In this thesis, we improved an existing structured light methodology to more accurately estimate tissue optical properties imaged in a single snapshot. The developed approach is a major enhancement of the traditional three-phase spatial frequency domain imaging system: It greatly simplifies the operational procedure while also maintaining high accuracy in optical property measurements .
Leveraging this improved approach, we have developed a low-cost, compact, and radial-view endoscope prototype. This prototype combines affordability with high functionality and a user-friendly design. To assess the performance and reliability of our endoscope, we conducted comprehensive evaluations involving tissue-mimicking phantoms, as well as ex vivo imaging of human wrist vessels and colorectal tissues. These evaluations demonstrated the prototype’s ability to extract the absorption and reduced scattering coefficients, thereby proving the prototype's ability to accurately capture the optical characteristics of biological tissues. The results from our study not only validate the effectiveness of the structured light approach in optical property assessment but also highlight the potential of our endoscopic prototype in enhancing diagnostic procedures for biological tissue imaging.
Language
English (en)
Chair
Professor Quing Zhu
Committee Members
Professor Song Hu Professor Adam Bauer
Included in
Bioimaging and Biomedical Optics Commons, Biomedical Devices and Instrumentation Commons, Vision Science Commons