Document Type
Technical Report
Publication Date
1991-10-01
Technical Report Number
WUCS-91-50
Abstract
When using random clone overlap based methods to make DNA maps, fragment matching mistakes, the incorrect matching of similar length restriction fragments, are a common problem that produces incorrect maps. This technical report discusses techniques for fragment splitting and fragment combining, which attempts to correct maps containing a fragment matching mistake, given that the location of the mistake is known. These techniques are based on operations that decompose and merge virtual fragments (a collection of matched real fragments), add virtual fragments to existing groups in the map and insert virtual fragments between existing groups in the map. Examples of applying these techniques to both contrived and actual DNA maps are presented.
Recommended Citation
Daues, James and Gillet, Will, "DNA Mapping Algorithms: Fragment Splitting and Combining" Report Number: WUCS-91-50 (1991). All Computer Science and Engineering Research.
https://openscholarship.wustl.edu/cse_research/668
Comments
Permanent URL: http://dx.doi.org/10.7936/K7W37TPW