Global Constructive Optimization of Vascular Systems

Authors

Manfred Georg, Washington University in St Louis
Tobias Preusser, Washington University in St Louis
Horst K. Hahn, Washington University in St Louis

Document Type

Technical Report

Department

Computer Science and Engineering

Publication Date

2010

Filename

WUCSE-2010-11.pdf

Technical Report Number

WUCSE-2010-11

Abstract

We present a framework for the construction of vascular systems based on optimality principles of theoretical physiology. Given the position and flow distribution of end points of a vascular system, we construct the topology and positions of internal nodes to complete the vascular system in a realistic manner. Optimization is driven by intravascular volume minimization with constraints derived from physiological principles. Direct optimization of a vascular system, including topological changes, is used instead of simulating vessel growth. A good initial topology is found by extracting key information from a previously optimized model with less detail. This technique is used iteratively in a multi-level approach to create a globally optimized vascular system. Most of this work was completed at Fraunhofer MeVis during the summer of 2004.

Comments

Permanent URL: http://dx.doi.org/10.7936/K7J101DB

Recommended Citation

Georg, Manfred; Preusser, Tobias; and Hahn, Horst K., "Global Constructive Optimization of Vascular Systems" Report Number: WUCSE-2010-11 (2010). All Computer Science and Engineering Research.
https://openscholarship.wustl.edu/cse_research/36