Title

Compositional Analysis of Homogeneous Regions in Human Genomic DNA

Authors

Eric C. Rouchka, Washington University in St. Louis
David J. States, University of Michigan

Document Type

Technical Report

Publication Date

2002-03-19

Filename

wucse-2002-2.pdf

DOI:

10.7936/K7GM85PV

Technical Report Number

WUCSE-2002-2

Abstract

Due to increased production of human DNA sequence, it is now possible to explore and understand human genomic organization at the sequence level. In particular, we have studied one of the major organizational components of vertebrate genome organization previously described as isochores (Bernardi, 1993), which are compositionally homogeneous DNA segments based on G+C content. We have examined sequence data for the existence of compositionally differing regions and report that while compositionally homogeneous regions are present in the human genome, current isochore classification schemes are too brad for sequence-level data.

Comments

Permanent URL: http://dx.doi.org/10.7936/K7GM85PV

Recommended Citation

Rouchka, Eric C. and States, David J., "Compositional Analysis of Homogeneous Regions in Human Genomic DNA" Report Number: WUCSE-2002-2 (2002). All Computer Science and Engineering Research.
https://openscholarship.wustl.edu/cse_research/1137