Heterochromatin and gene regulation in Drosophila

Authors

Sarah C.R. Elgin, Washington University in St. LouisFollow

Author's School

Arts & Sciences

Author's Department

Biology

Document Type

Article

Publication Date

4-1996

Originally Published In

Elgin SC. Heterochromatin and gene regulation in Drosophila. Curr Opin Genet Dev. 1996;6(2):193–202. doi:10.1016/s0959-437x(96)80050-5

Abstract

We have recently learned more about the biochemistry of heterochromatin and about how heterochromatic environments affect gene function. New findings have emphasized the distinctions between telomeric and pericentric heterochromatin in Drosophila and have suggested a mosaic structure within pericentric heterochromatin. Theories concerning the mechanism of inactivation of euchromatic genes in heterochromatic environments have been tested using transgenes inserted into heterochromatin. The current data support a competition/chromatin structure model, in which multiprotein repressor complexes compete with transcriptional activators to assemble an active or inactive chromatin structure.

Comments

© Current Biology Ltd

ORCID

https://orcid.org/0000-0002-5176-2510 [Elgin]

Recommended Citation

Elgin, Sarah C.R., "Heterochromatin and gene regulation in Drosophila" (1996). Biology Faculty Publications & Presentations. 213.
https://openscholarship.wustl.edu/bio_facpubs/213