Mass spectrometry Approaches: Quinone Toxicity, Protein Affinity and Nanoliter Analysis

Author

Tingting Tu, Washington University in St. Louis

Abstract

Method development combined with the significant advances of mass spectrometry (MS) promotes versatility of MS applications to biological research of both small molecules and macromolecules. In this thesis, three aspects of the application of MS-based approaches are discussed; they include (1) properties and their implications on toxicity of biologically important quinones, (2) sample preparation for nanoliter analysis, and (3) affinities of antibody-peptide interactions.

Committee Chair

Michael L. Gross

Committee Members

John-Stephen A. Taylor, Robert Blankenship, Liviu Mirica, Timothy Holy, Jeffrey P. Henderson

Comments

Permanent URL: https://doi.org/10.7936/K75Q4TBZ

Degree

Doctor of Philosophy (PhD)

Author's Department

Chemistry

Author's School

Graduate School of Arts and Sciences

Document Type

Dissertation

Date of Award

Winter 12-15-2010

Language

English (en)

DOI

https://doi.org/10.7936/K75Q4TBZ

Recommended Citation

Tu, Tingting, "Mass spectrometry Approaches: Quinone Toxicity, Protein Affinity and Nanoliter Analysis" (2010). Arts & Sciences Theses and Dissertations. 626.

The definitive version is available at https://doi.org/10.7936/K75Q4TBZ