Date of Award

Winter 12-15-2014

Author's School

Graduate School of Arts and Sciences

Author's Department

Chemistry

Degree Name

Doctor of Philosophy (PhD)

Degree Type

Dissertation

Abstract

Isotope harvesting from heavy-ion fragmentation facilities is a potential source of isotopes of interest for applications research. With the upgrade of the National Superconducting Cyclotron Laboratory (NSCL) to the Facility for Rare Isotope Beams (FRIB) usable quantities of many isotopes of interest will be produced and available for harvest from an aqueous beam dump. If available, these isotopes would be of interest to a broad range of applications such as medicine, geology, and stockpile stewardship. Preliminary experiments were performed at the NSCL in order to determine the feasibility of isotope harvesting at (FRIB).

A water target station that consisted of a 100 mL beam dump was designed and built to collect secondary beams at the NSCL. This target station could be controlled remotely from outside of the experimental vault allowing for multiple collections with minimal exposure to radioactivity. Three secondary beam collections were made with the water target station: a 24Na beam, an analyzed 67Cu beam, and an unanalyzed 67Cu beam.

To test the durability of the target station, a 73% pure 85 MeV/u 24Na secondary beam was stopped and collected in the beam dump. Multiple collections were made with currents up to 2 x 106 particles per second without visible radiolytic damage to the target cell. The station operated without any observed release of radiolytic gases, spills, or loss of radioactive liquids.

The water target station was then used collect a 77% pure 76 MeV/u 67Cu secondary beam. 67Cu was separated from the other secondary beam contaminants with an average recovery of 88 ± 3 % and used to radiolabel an antibody. The radiochemical yield of 67Cu-NOTA-Bz-NCS-Trastuzumab was >95%.

To better mimic the conditions that would be present in the beam dump at FRIB an unanalyzed beam was collected. This secondary beam was 2.6% pure and contained many contaminants most of which are located in period four of the periodic table. 67Cu was separated from the beam contaminants with an average recovery of 74 ± 4% and a radiochemical purity of >99%. The purified 67Cu was then used to radiolabel NOTA conjugated Panitumumab antibodies and injected into HCT-116 tumor bearing mice via tail vein injection. A five day biodistribution profile was obtained and the tumor uptake of 67Cu-NOTA-Bz-NCS-Panitumumab was measured to be 12.5 ± 0.7 % ID/g.

Language

English (en)

Chair and Committee

Lee G Sobotka

Committee Members

Suzanne E Lapi, John R Bleeke, Robert Charity, Richard Laforest, Demetrios G Sarantities

Comments

Permanent URL: https://doi.org/10.7936/K7SQ8XJ0

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