ORCID
http://orcid.org/0000-0002-1839-2378
Date of Award
Spring 5-15-2023
Degree Name
Doctor of Philosophy (PhD)
Degree Type
Dissertation
Abstract
Anhedonia transcends psychiatric diagnostic boundaries (e.g., depression, schizophrenia, PTSD) and is a marker of severe dysfunction and treatment resistance. Convergent evidence from non-human animal models and initial human studies suggests that elevated inflammatory signaling may induce anhedonia. However, the mechanisms underlying this association and the specific forms of reward processing that may be affected remain largely unknown. Here, two studies were conducted examining whether variability in reward-related brain measures and behavior may plausibly contribute to inflammation-related differences in reward processing. In the first study, data from children of European American ancestry of the Adolescent Brain Cognitive Development (ABCD) study of children (n=5,512 8-10 year olds at baseline) was used to test whether polygenic risk for heightened inflammatory signaling was associated with variability in reward-related corticostriatal circuit brain structure, reward-related behavior, and anhedonia. Polygenic scores of CRP were associated with total brain volume (β = -0.027, p = 0.04) but not anhedonia symptoms (|β|s < 0.364, ps < 0.05). In the second study, fasting blood, electroencephalography (EEG), behavioral, and self-report data were collected from young adults (n=116, 18–35-year-olds) to test whether circulating cytokines (n=69) are correlated with distinct aspects of behavioral (i.e., reward learning, delay discounting, effort expenditure) and neural (i.e., reward positivity [RewP]) indices of reward processing. No significant associations across measures were found (|β|s < 0.173, ps <0.05). These studies point to the critical need for future work examining the interplay of immune and neural pathways implicated in reward processing deficits in anhedonia.
Language
English (en)
Chair and Committee
Ryan Bogdan
Committee Members
Deanna Barch, Denise Head, Renee Thompson, Nicole Karcher,
Recommended Citation
Bondy, Erin, "Inflammation and Reward-related Neural and Behavioral Phenotypes" (2023). Arts & Sciences Electronic Theses and Dissertations. 2833.
https://openscholarship.wustl.edu/art_sci_etds/2833