Abstract

Antibiotics have greatly reduced the number of deaths caused by infectious diseases for the last 70 years, but as a result of overuse, antimicrobial resistance emerged. Resistance is the major reason why most traditional antibiotics currently have reduced clinical efficacy. However, there is still a drive to overcome this resistance in a variety of ways. There are two main avenues of research to overcome resistance; to discover and develop new drug candidates acting on new targets and pathways, and to determine the mechanisms of antibiotic resistance in order to combat it through multi-drug therapies, bringing back the effectiveness of antibiotics used in the past. My research uses both approaches to address the antibiotic resistance crisis with an emphasis on leveraging mechanistic enzymology to inspire the development of new antibacterial therapeutic strategies.

Committee Chair

Timothy Wencewicz

Committee Members

John-Stephen Taylor, Gautam Dantas, Jeffrey Henderson, Meredith Jackrel,

Degree

Doctor of Philosophy (PhD)

Author's Department

Chemistry

Author's School

Graduate School of Arts and Sciences

Document Type

Dissertation

Date of Award

Winter 1-15-2021

Language

English (en)

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