Date of Award
Doctor of Philosophy (PhD)
The studies outlined in this thesis provide several new insights into Msln-related pathways necessary for peritoneal immune responses and mucosal repair. We found that Msln and its binding partner mucin 16 from mesothelium influenced peritoneal and pleural macrophage differentiation. We found that Msln was required for proper tissue repair after colonic biopsy injury and was required for maximal polyp growth in APCMin/+ mice. Overall, this work describes mesothelial and epithelial-derived factors that are important for tissue resident macrophage differentiation and wound repair after colonic mucosal injury. Understanding the complex interactions between stromal cells and immune cells will lead to better treatments for intestinal diseases such as inflammatory bowel disease and tumor associated macrophage-mediated tumorigenesis.
Chair and Committee
Thaddeus S. Stappenbeck
Paul M. Allen, Michael S. Diamond, Brian T. Edelson, Emil Unanue,
Lai, Chin-Wen, "Mesothelium-derived factors shape tissue resident macrophage" (2019). Arts & Sciences Electronic Theses and Dissertations. 1920.