Abstract

The studies outlined in this thesis provide several new insights into Msln-related pathways necessary for peritoneal immune responses and mucosal repair. We found that Msln and its binding partner mucin 16 from mesothelium influenced peritoneal and pleural macrophage differentiation. We found that Msln was required for proper tissue repair after colonic biopsy injury and was required for maximal polyp growth in APCMin/+ mice. Overall, this work describes mesothelial and epithelial-derived factors that are important for tissue resident macrophage differentiation and wound repair after colonic mucosal injury. Understanding the complex interactions between stromal cells and immune cells will lead to better treatments for intestinal diseases such as inflammatory bowel disease and tumor associated macrophage-mediated tumorigenesis.

Committee Chair

Thaddeus S. Stappenbeck

Committee Members

Paul M. Allen, Michael S. Diamond, Brian T. Edelson, Emil Unanue,

Comments

Permanent URL: https://doi.org/10.7936/regx-j539

Degree

Doctor of Philosophy (PhD)

Author's Department

Biology & Biomedical Sciences (Immunology)

Author's School

Graduate School of Arts and Sciences

Document Type

Dissertation

Date of Award

Summer 8-15-2019

Language

English (en)

Author's ORCID

http://orcid.org/0000-0002-7691-009X

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