ORCID
http://orcid.org/0000-0002-7691-009X
Date of Award
Summer 8-15-2019
Degree Name
Doctor of Philosophy (PhD)
Degree Type
Dissertation
Abstract
The studies outlined in this thesis provide several new insights into Msln-related pathways necessary for peritoneal immune responses and mucosal repair. We found that Msln and its binding partner mucin 16 from mesothelium influenced peritoneal and pleural macrophage differentiation. We found that Msln was required for proper tissue repair after colonic biopsy injury and was required for maximal polyp growth in APCMin/+ mice. Overall, this work describes mesothelial and epithelial-derived factors that are important for tissue resident macrophage differentiation and wound repair after colonic mucosal injury. Understanding the complex interactions between stromal cells and immune cells will lead to better treatments for intestinal diseases such as inflammatory bowel disease and tumor associated macrophage-mediated tumorigenesis.
Language
English (en)
Chair and Committee
Thaddeus S. Stappenbeck
Committee Members
Paul M. Allen, Michael S. Diamond, Brian T. Edelson, Emil Unanue,
Recommended Citation
Lai, Chin-Wen, "Mesothelium-derived factors shape tissue resident macrophage" (2019). Arts & Sciences Electronic Theses and Dissertations. 1920.
https://openscholarship.wustl.edu/art_sci_etds/1920
Included in
Allergy and Immunology Commons, Developmental Biology Commons, Immunology and Infectious Disease Commons, Medical Immunology Commons
Comments
Permanent URL: https://doi.org/10.7936/regx-j539