Abstract
Thoracic aortic aneurysms (TAAs) are characterized by dilation and structural weakening of the aortic wall [1]. If left untreated, aortic dissections or life-threatening ruptures can occur. While current treatment options primarily involve minimally invasive surgical procedures, a deeper understanding of the underlying molecular and mechanical changes in the vessel wall could direct new forms of treatment. This report investigates the role of elastic fibers in the extracellular matrix (ECM) and the contribution of endothelial cells in maintaining aortic contractility. The overall goal is to observe how elastin degradation contributes to vessel dysfunction.
Document Type
Final Report
Class Name
Mechanical Engineering and Material Sciences Independent Study
Language
English (en)
Date of Submission
5-10-2025
Recommended Citation
Trani, Bebel B., "Elastin and Endothelium’s Role in Aortic Contraction: A Wire Myography Study in Adult Mice" (2025). Mechanical Engineering and Materials Science Independent Study. 291.
https://openscholarship.wustl.edu/mems500/291