The purpose of this study was to apply bench-top imaging (optical coherence tomography or OCT) to small intestinal tissues from wild-type (normotensive) and angiotensin II (AngII)- treated (hypertensive) mice, focusing on the visualization of different anatomical structures and geometric characterization of the intestinal wall under applied loading. Quantifying such properties of the intestinal wall will allow for further understanding of the functionality of the gastrointestinal tract (GI), the effect of hypertension on intestinal mechanical properties, and the relationship between chronic GI inflammation and tissue remodeling on the progression to colorectal cancer. To supplement the images gathered from OCT imaging (loaded and unloaded samples from wild-type and AngII models), microstructural composition and organization was assessed by histological and immunohistochemical analysis.
Mechanical Engineering and Material Sciences Independent Study
Date of Submission
Reed, Sara-Marie and Bersi, Matthew, "Geometric Characterization of Wild-Type and AngII-Treated Mouse Intestines under Applied Loading" (2023). Mechanical Engineering and Materials Science Independent Study. 234.