The purpose of this study was to apply bench-top imaging (optical coherence tomography or OCT) to small intestinal tissues from wild-type (normotensive) and angiotensin II (AngII)- treated (hypertensive) mice, focusing on the visualization of different anatomical structures and geometric characterization of the intestinal wall under applied loading. Quantifying such properties of the intestinal wall will allow for further understanding of the functionality of the gastrointestinal tract (GI), the effect of hypertension on intestinal mechanical properties, and the relationship between chronic GI inflammation and tissue remodeling on the progression to colorectal cancer. To supplement the images gathered from OCT imaging (loaded and unloaded samples from wild-type and AngII models), microstructural composition and organization was assessed by histological and immunohistochemical analysis.

Document Type

Final Report

Author's School

McKelvey School of Engineering

Author's Department

Mechanical Engineering and Materials Science

Class Name

Mechanical Engineering and Material Sciences Independent Study

Date of Submission