Effect of Freeze Thaw Cycles on Elbow Mobility in a Long Evans Rat


Throughout the 2022 Fall semester I worked in Dr. Lake’s musculoskeletal soft tissue lab on the Post Traumatic Joint Contracture(PTJC) project. Previous work on this project used a rat model of the elbow to explore different factors affecting this disease and potential treatments. There are many different tests used to quantify the rats progress through this condition. One is range of motion testing. The typical procedure for this project is to sacrifice the animals and then freeze them before performing range of motion testing. This project tested the animals range of motion immediately after sacrifice and then again after the elbow had been frozen to test whether there would be a change in the range of motion(flexion-extension). It was found that the extension angle slowly increased between the fresh test and each freeze thaw cycle. There was a lot of fluctuation seen between the total range of motion for each cycle, but further experimentation would be needed to find a concrete relationship.

Document Type

Final Report

Author's School

McKelvey School of Engineering

Author's Department

Mechanical Engineering and Materials Science

Class Name

Mechanical Engineering and Material Sciences Independent Study

Date of Submission


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