Date of Award
Master of Science (MS)
Endovascular procedures require access to distal anatomical sites through the vasculature using catheters and guidewires. Quantitative frameworks for device behavior during procedures hold the potential to drive device design through greater understanding of the mechanical behavior of endovascular devices, and offer the potential to personalize care based on a patient's particular vascular anatomy. However, data that would facilitate this technology are lacking, partly due to undisclosed material properties from manufacturers and partly due to the intricate variations along the length of each device due to material changes and the intersections between them. We developed a three-point bend test methodology on a custom apparatus to measure lengthwise flexural rigidity profiles of endovascular devices commonly used to target the neurovasculature. The methodology demonstrated high repeatability and was able to characterize transition zones. We applied the method to generate the first comprehensive, quantitative library of device flexural rigidities, spanning guidewires, intermediate guide catheters, and long sheaths. Additional plots examining relationships between flexural rigidity, device diameter, and length reveal application-specific trends in flexural properties. This methodology and the data allow for standardized characterization and comparisons to aid device selection, and have the potential to both enhance surgical planning and inform future innovation.
Guy M. Genin, Joshua W. Osbun
Matthew R. Bersi Mohamed A. Zayed