Date of Award

Spring 5-2023

Author's School

McKelvey School of Engineering

Author's Department

Biomedical Engineering

Degree Name

Master of Science (MS)

Degree Type



Neutrophil extracellular traps involve the rapid translocation of DNA to the outside of the cell under certain stimuli. This structure forms a fibrous network that is able to limit the spread of pathogens and to kill microorganisms. It has also been shown to be present in various pathological processes such as inflammation, autoimmune diseases, and cancer metastasis. Currently, the formation process of NETs in vivo is being extensively studied. However noninvasive detection and quantitation has yet to be achieved. A class of PET tracers are described here that consists of a DNA dye as the backbone that is labeled with an emerging positron emitting isotope of research and clinical interest, 44Sc. We describe the synthesis and radiolabeling of several NET probes and their in vivo pharmacokinetics.


English (en)


Daniel L.J. Thorek, PhD, Radiology, Biomedical Engineering

Committee Members

Hanwen Zhang, PhD, Radiology Buck Rogers, PhD, Radiation Oncology Michael Nickels, PhD, Radiology