Synthesis, Radiolabeling and Evaluation of a suite of Tracers with 44Sc for Detecting Extracellular DNA
Date of Award
Master of Science (MS)
Neutrophil extracellular traps involve the rapid translocation of DNA to the outside of the cell under certain stimuli. This structure forms a fibrous network that is able to limit the spread of pathogens and to kill microorganisms. It has also been shown to be present in various pathological processes such as inflammation, autoimmune diseases, and cancer metastasis. Currently, the formation process of NETs in vivo is being extensively studied. However noninvasive detection and quantitation has yet to be achieved. A class of PET tracers are described here that consists of a DNA dye as the backbone that is labeled with an emerging positron emitting isotope of research and clinical interest, 44Sc. We describe the synthesis and radiolabeling of several NET probes and their in vivo pharmacokinetics.
Daniel L.J. Thorek, PhD, Radiology, Biomedical Engineering
Hanwen Zhang, PhD, Radiology Buck Rogers, PhD, Radiation Oncology Michael Nickels, PhD, Radiology
Available for download on Wednesday, April 17, 2024
Bioimaging and Biomedical Optics Commons, Organic Chemistry Commons, Radiochemistry Commons, Radiology Commons