Development of Optical Coherence Tomography Angiography System for Mouse Eye Imaging And Measurement of Vasodilation
Date of Award
Master of Science (MS)
Optical coherence tomography angiography (OCTA) is broadly known as a non-invasive technology that allows examining the retinal and choroidal vasculatures, alternative to fluorescein angiography. In this study, we have developed an optical coherence tomography (OCT) system for imaging the mouse eye. We measure the retinal thickness, which is 216.53um. We apply OCTA to characterize the quantitative change in vessel diameter and the perfusion density of the retina after the wild-type mice are administered the adenosine or inhale carbon dioxide. Comparing the images acquired one minute and 5 minutes after the injection or CO2 inhalation with the baseline, distinct changes have been observed to demonstrate the efficacy of dilating the retinal vessels. Our results suggest that OCTA is a reliable and valuable technology to detect and monitor dynamic changes in retinal vasculatures associated with physiological perturbations.
Chao Zhou, Biomedical Engineering
Quing Zhu, Song Hu
Available for download on Tuesday, December 26, 2023