Date of Award

Summer 8-2018

Author's Department

Mechanical Engineering & Materials Science

Degree Name

Master of Science (MS)

Degree Type

Thesis

Abstract

Reference point indentation (RPI) has gained interest among translational scientists and clinicians in musculoskeletal research. BioDent (cyclic RPI) and OsteoProbe RUO (impact RPI) devices have been used in recent clinical studies of fracture risk and disease, as well as in cadaver studies to explore their underlying sensitivity to composition and whole-bone mechanical behavior. This thesis describes two experiments utilizing RPI technology. In the first experiment, the relationship between tibial RPI parameters and vertebral body mechanical behavior is explored. Indentation distance increase (IDI) from cyclic RPI is negatively correlated with L4 failure load (r = -0.596, p = 0.031), modulus (r = -0.553, p = 0.057), and energy to failure (r = -0.578, p = 0.042). No significant relationship is found between impact RPI and L4 mechanical behavior. In the second experiment, the time- and depth-dependent mechanical behavior of a murine osteoarthritis model is determined using cyclic RPI.

Language

English (en)

Chair

Simon Tang

Committee Members

Spencer Lake Ruth Okamoto

Available for download on Friday, December 15, 2045

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