Date of Award
Master of Science (MS)
Aortoiliac occlusive disease is a subsequent disease of atherosclerosis involving the accumulation of plaque on the lining of the artery wall causing the artery lumen to narrow at the site of the aortic bifurcation. To prevent foreseeable embolization threats or ischemia, revascularization of the aortic bifurcation is commonly treated by arterial stenting. The most common practice of arterial stenting of aortoiliac occlusive disease is using balloon expandable stents. Traditionally, in order to prevent encroachment and/or occlusion of one iliac system by the stenting of the other, two balloon expandable stents are placed in the aortic bifurcation adjacently (kissing) at the time of deployment. The kissing stent procedure, while commonly used in clinical practices, has major disadvantages in the design. The stents used for this procedure are usually outside the Food and Drug Administration (FDA) approved Instructions For Use (IFU) and have sub-optimal long-term patency. It is because of these real-world disadvantages that a novel aortoiliac, fenestrated (AIFEN), tapered, balloon expandable stent design has been proposed as a superior treatment technique to aortoiliac atherosclerotic occlusive disease. In this thesis, computer-aided design models of the aortic birfucation have been generated and computation blood flow fluid dynamics were evaluated between the traditional kissing stent configuration and the novel AIFEN design. Additionally, three various length parameters involved with the design of the fenestration, at 5mm, 10mm, and 15mm, respectively, were simulated to provide an optimized alternative to the current solutions used in industry. Coefficients for comparative analysis including mass flow rate, average velocity at the common iliac outlets, velocity contours and vectors, and blood flow vorticity. Superiority of the AIFEN design treatment method over the kissing stent aortoiliac procedure, in addition to the best size fit of the fenestration needed for this procedure, is demonstrated in this thesis.
Dr. Mohamed Zayed
Dr. Mohamed Zayed, Dr. Guy Genin, Dr. Damena Agonafer