CBAC Seminar Series Videos
 
Quantitative T-wave Alternans Analysis for Sudden Cardiac Death Risk Assessment and Guiding Therapy: Answered and Unanswered Questions

Title

Quantitative T-wave Alternans Analysis for Sudden Cardiac Death Risk Assessment and Guiding Therapy: Answered and Unanswered Questions

Files

Link to Full Video

Stream Seminar Video

Date

Fall 12-19-2016

Document Type

Seminar Series

Abstract

Identification of individuals at risk for sudden cardiac death (SCD), the main cause of adult mortality in developed countries, remains a major challenge. The scope of this public health problem is sizeable, as one million SCDs occur annually worldwide. In 30% to 40% of cases, death is the first indication of underlying heart disease. The main contemporary noninvasive marker, left ventricular ejection fraction (LVEF), has not proved adequately reliable, as the majority of individuals who die suddenly have relatively preserved cardiac mechanical function. Monitoring of T-wave alternans (TWA), a beat-to-beat fluctuation in ST-segment or T-wave morphology, on ambulatory electrocardiogram ECG (AECG) is an attractive approach on both scientific and clinical grounds. Exercise stress testing and AECG-based TWA monitoring can be performed in the flow of routine clinical evaluation. This presentation will address: (1) electrophysiologic and ionic mechanisms underlying TWA’s predictivity, (2) principles and practical aspects of TWA monitoring during exercise and daily activity, (3) clinical evidence supporting this approach to SCD risk stratification, and (4) current and potential application in guiding medical therapy as well as the main unanswered questions.

Biography

Associate Professor in the Department of Environmental Health Associate Professor of Medicine, Harvard Medical School Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard University

Research/Clinical Interests

https://connects.catalyst.harvard.edu/Profiles/display/Person/80524

Publications

https://www.ncbi.nlm.nih.gov/pubmed?dispmax=25&pmfilter_EDatLimit=No%20Limit&cmd_current=Limits&orig_db=PubMed&cmd=Search&doptcmdl=DocSum&term=Verrier%20RL

Flyer

https://wustl.box.com/s/7gv4vvu5ryqgxiwxus9rdlf3hletg1mh

Quantitative T-wave Alternans Analysis for Sudden Cardiac Death Risk Assessment and Guiding Therapy: Answered and Unanswered Questions

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