From Protein to Mouse to Human: cBIN1 in E-C Coupling and Heart Failure Management
The Hong Lab has cloned the cardiac isoform of the membrane deformation protein BIN1, which we refer to as cBIN1. The story of cBIN1 originated as a protein trafficking finding, identifying how calcium channels are delivered to T-tubule membrane. In subsequent studies, they have found that cBIN1 forms membrane microdomains in T-tubule membrane, affecting calcium transients, dyad organization, and membrane excitability. In heart failure, cBIN1 is reduced. cBIN1 is also turned over into blood from viable cardiomyocytes. In clinical studies, they are finding that cBIN1 provides a window into the metabolic health of heart muscle and may help in clinical decision making.
Assistant Professor of Medicine, Cedars-Sinai Heart Institute Cedars-Sinai Medical Center, University of California, Los Angeles (UCLA)