"How the Heart Must Work When It Fills", or "How Kinematic Modeling Can Elucidate Physiology"
Stream Seminar Video
The mechanism by which the heart fills with blood (diastolic function) has remained a topic of permanent controversy since William Harvey (1628) characterized the circulatory system. Because technology (echocardiography, MRI, CT, electronic catheters) allows superb data acquisition of anatomy, structure, motion and hemodynamics—new insights into filling can be achieved by application of engineering principles (Newton’s laws, volume conservation, incompressibility, causality, …). I will describe selected aspects of how the heart works from the perspective of a cardiologist/physiologist—and then show that by invoking basic engineering and physical principles, selected aspects of diastolic function become apparent. The ability of kinematic modeling to explain previously observed – but heretofore unexplained – physiology, and even to predict ‘new’ physiology will be included. Some clinical examples will highlight its translational potential in the real world of cardiology.
Associate Professor of Medicine, Physiology, Physics and Biomedical Engineering Washington University in St. Louis School of Medicine, MO