Lucie Delemotte Ph.D.
Voltage-gated ion channels are the membrane proteins whose opening and closing are responsible for the propagation of action potential in excitable cells. Their dysfunction leads to diseases such as cardiac arrhythmias, epilepsy or muscle ataxia. As such, they constitute major drug targets.
Voltage-sensitive ion channels function depends in a large part on their structure, and high-resolution structures of prototype channels have been known since the early 2000s. Nevertheless, we still lack a detailed understanding of their dynamic behavior as well as the structural ensemble that make up their functional cycle. Both of these aspects are critical for designing innovative and ...Read More
Eleonora Grandi Ph.D.
Nathan Huebsch Ph.D.
Joseph C. Wu M.D., Ph.D.
Richard W. Aldrich Ph.D.
Andrew R. Marks M.D.
Ryanodine receptor (RyR) channels are required for release of calcium from intracellular stores, aprocess essential for many cellular functions including excitation-contraction (EC) coupling in skeletal and cardiac muscle, and hormone and neurotransmitter release. They are the largest ion channels, comprised of the four identical -565 kDa channel-forming protomers, as well as regulatory subunits, enzymes and their respective targeting/anchoring proteins, in a macromolecular complex that exceeds three million daltons. We have obtained high-resolution cryo-electron microscopy (Cryo-EM) reconstructions from highly purified rabbit skeletal muscle RyR1 in the open and closed states. Our data reveal that RyRs are members of the six transmembrane ...Read More
Riccardo Olcese Ph.D.
Advancements in Implantable Cardioverter Defibrillator Therapy: Focus on Lead Technology and Defibrillation
Andrea M. Russo M.D., F.A.C.C., F.H.R.S.