Penelope A. Boyden Ph.D
Alfred E. Buxton M.D.
David J. Callans M.D., F.H.R.S.
David Fedida B.M., B.Ch., Ph.D.
Alan Garfinkel Ph.D
Mathematical models of cardiac arrhythmias come in two distinct forms. High-dimensional, biophysically detailed models give us realism; they talk about biophysical quantities that can be experimentally and clinically altered.
But there is another critical kind of modeling: Low-dimensional modeling tries to isolate the essential dynamical phenomena responsible for a qualitative outcome. It gives us deeper insights into causal mechanisms. The most important technique of low-dimensional modeling is bifurcation theory. A bifurcation is a qualitative change in the solution to a differential equation, as a key parameter is varied. Identification of these key parameters then becomes the central task, because it ...Read More
Michael Glikson M.D.
Patrick T. Elinor M.D., Ph.D
Atrial fibrillation (AF) affects over 3 million individuals in the US and 4.5 million individuals in Europe. In addition, AF is associated with an increased risk of stroke, dementia, heart failure, death and health care costs. Many AF risk factors have been identified including aging, cardiovascular disease, and family history. Although heritable forms of AF were previously considered rare, we have established evidence of substantial AF heritability over the last decade. Genome-wide association studies (GWAS) provide a powerful tool to identify common variants underlying disease risk. In 2007 a GWAS for AF identified a locus on chromosome 4q25. Later that ...Read More
Glenn I. Fishman M.D., F.A.C.C., F.A.H.A., F.A.C.P., F.H.R.S
Our laboratory has been interested in multiple facets of cardiac electrophysiology and arrhythmia mechanisms, with a particular focus on identifying novel regulators of cardiac excitability, impulse propagation, and arrhythmia susceptibility. Our most recent studies seek to decipher the mechanisms responsible for specification, maturation and function of the specialized cardiac conduction system and identifying novel transcriptional regulators that influence cardiomyocyte electrophysiological diversity and integrated cardiac excitability. I will describe the role of two novel transcription factors (one recently reported and the second still a work in progress) that appear to play critical roles in establishing functional diversity throughout individual compartments of ...Read More
Richard W. Gross M.D., Ph.D
Francis E. Marchlinski M.D.