Searchable Title

Utility of the Dependence Scale in dementia: Validity, meaningfulness, and health economic considerations. Copyright: Creative Commons License.

Reference Type

Journal Article

Authors, Section

Zhu, C. W.; Bruinsma, B. G.; Stern, Y.

Title, Section

Utility of the Dependence Scale in dementia: Validity, meaningfulness, and health economic considerations. Copyright: Creative Commons License.

Publication Year

2018

Journal Title

Alzheimer’s Research & Therapy

Volume

10

Issue

1

Pages

78

Availability

online

PMID

PMID: 30103820

DOI

10.1186/s13195-018-0414-7

Abstract

BACKGROUND: The concept of dependence has been proposed as a unified representation of disease severity to quantify and stage disease progression in a manner more informative to patients, caregivers, and healthcare providers. METHODS: This paper provides a review of the Dependence Scale (DS) as a quantitative measure of Alzheimer's disease severity, its properties as an outcome measure, a metric of disease progression, and a correlate of medical costs. RESULTS: The literature supports the notion that the DS is related to, but distinct from, key severity measures, including cognition, function, and behavior, and captures the full spectrum of patient needs. It also presents as a useful measure for assessing disease progression. CONCLUSIONS: Results underscore the importance of the DS as a unique endpoint in Alzheimer's disease clinical trials, providing important information about the impact of therapeutic interventions. The DS also is a useful measure for economic evaluation of novel interventions aimed at delaying progression.

This document is currently not available here.

Share

COinS