Searchable Title

Memory and Executive Screening (MES): A Brief Cognitive Test for Detecting Mild Cognitive Impairment. Copyright: Creative Commons License.

Reference Type

Journal Article

Authors, Section

Guo, Qi-hao; Zhou, Bin; Zhao, Qian-hua; Wang, Bei; Hong, Zhen

Title, Section

Memory and Executive Screening (MES): A Brief Cognitive Test for Detecting Mild Cognitive Impairment. Copyright: Creative Commons License.

Publication Year

2012

Journal Title

BMC Neurology

Volume

12

Issue

Oct. 11

Pages

119

Availability

online

PMID

PMID: 23050770

DOI

10.1186/1471-2377-12-119

Abstract

BACKGROUND: Mild cognitive impairment (MCI), defined as a transitional zone between normal cognition and dementia, requires a battery of formal neuropsychological tests administered by a trained rater for its diagnosis. The objective of this study was to develop a screening tool for MCI. METHODS: One hundred ninety seven cognitively normal controls (NC), one hundred sixteen patients with amnestic MCI -single domain (aMCI-sd), one hundred ninety five patients with amnestic MCI-multiple domain (aMCI-md), and two hundred twenty eight patients with mild Alzheimer's disease (AD) were evaluated by comprehensive neuropsychological tests and by the Memory and Executive Screening (MES). RESULTS: Correlation analysis showed that the three indicators of the MES were significantly negatively related with age (P<0.05), yet not related with education (P>0.05). There was no ceiling or floor effect. Test completion averaged seven minutes (421.14±168.31 seconds). The receiver operating characteristics (ROC) analyses performed on the aMCI-sd group yielded 0.89 for the area under the curve (AUC) (95% CI, 0.85-0.92) for the MES-total score, with sensitivity of 0.795 and specificity of 0.828. There was 81% correct classification rate when the cut-off was set at less than 75. Meanwhile, the aMCI-md group yielded 0.95 for the AUC (95% CI, 0.93-0.97) for the MES-total score, with sensitivity of 0.87 and specificity of 0.91, and 90% correct classification rate when the cut-off was set at less than 72. CONCLUSION: The MES, minimally time-consuming, may be a valid and easily administered cognitive screening tool with high sensitivity and specificity for aMCI, with single or multiple domain impairment.

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