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Theses/Dissertations from 2021

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Functional and therapeutic insights into Wolfram syndrome pathophysiology, Damien C. Abreu

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Transcriptional Control of Dendritic Cell Function and Development, David Alexander Anderson Iii

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Genetics of Pediatric Musculoskeletal Disorders, Lilian Antunes

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Dedicated Interneuronal Microcircuits Regulated by Behavioral State, Moises William Arriaga

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Homeostatic T Cell Receptor Interactions with Self-Peptide Tune CD4+ T Cell Function, Juliet Marie Bartleson

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The Role of Soil Microbes in Improving Tallgrass Prairie Restoration and Rare Plant Reintroduction, Rachel Ellen Becknell

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Defining the epigenetic and transcriptional regulatory mechanisms by which hRSV NS1 alters host transcriptional response, Nina Rose Beri

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Potentiation of TMEM16A Currents by CLCA1 in Cystic Fibrosis Airway, Kayla Berry

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Understand and predict microbiome and resistome dynamics in response to perturbations across diverse populations and environments, Manish Boolchandani

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The evolutionary history of Camelina Crantz (Brassicaceae) and domestication of the biofuel crop, C. sativa (L.) Crantz, Jordan Brock

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Phenotyping and Preclinical Meta-Analysis of Behavioral Outcomes from Complete Freund’s Adjuvant-Induced Inflammatory Pain in the Rodent Hind-paw, Dominika J. Burek

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Association of Structural Variation (SV) with Cardiometabolic Traits in Finns, Lei Chen

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RhoA Mediated Juxtacrine Regulation of Glucagon Secretion, Yong Hee Chung

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Understanding the Roles of DNA Methylation and MeCP2 in Neuronal Enhancer Control, Adam Clemens

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Dissecting the Molecular Mechanism of Familial Cardiomyopathies, Sarah Ruth Clippinger Schulte

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Functional Interrogation of JAK2 and ASXL1 Mutations in Myeloproliferative Neoplasms, Taylor Brost Collins

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Deep Multi-omics Investigations Elucidate Novel Oncogenesis Paradigms, Therapeutic Targets, and Mechanisms of Treatment Resistance in Cancer, Daniel Cui Zhou

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Modeling Small Molecule Metabolism in Human Liver Microsome to Better Predict Toxicity Risk, Na Le Dang

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Polygenic and Transcriptomic Studies in Neurodegeneration: Towards More Precise Medicine., Umber Dube

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Examining Early Interactions between Innate Airway Resident Immune Cells and Mtb-specific Factors during Pulmonary Infection with Mycobacterium tuberculosis, Micah D. Dunlap

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C. elegans Response to Cadmium Toxicity, Brian James Earley

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Investigating the Integration-Independent Role of HIV-1 IN in the Viral Life Cycle, Jennifer Elliott

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Protein Synthesis Adaptation to the AU-Rich Transcriptome of Plasmodium falciparum, Jessey Lee Erath

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Understanding Immune Responses with Single-Cell RNA Sequencing and CyTOF Across Different Diseases and Model Organisms, Ekaterina Esaulova

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Role of 4R tau in astrocyte-mediated neuronal toxicity and the progression of neurodegenerative disease, Lubov Alexandra Ezerskiy

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Testing Janzen’s Physiological Barrier Hypothesis Through Experimental Evolution and Biogeographic Studies on Sister Species Pairs, Vincent John Fasanello

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Computational Approaches for Screening Drugs for Bioactivation, Reactive Metabolite Formation, and Toxicity, Noah Flynn

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Identifying Subpopulation-level Methylation Patterns in Hematological Malignancies, Jerry Fong

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The Regulation of Plasmodium falciparum Metabolism by Haloacid Dehalogenase Proteins, Philip Frasse

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Sex Differences in the Role of Cornichon Homolog-3 on Spatial Memory and Synaptic Plasticity, Hannah Elizabeth Frye

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Analysis of Structural Variation and mtDNA Copy Number in Finns, Liron Ganel

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The Genetic Basis of Adaptation to Environmental Stress in Two Grass Genomic Model Systems, David Mitchell Goad

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Regulation of genome architecture by chromatin remodeling in the brain, Jared Vega Goodman

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The Role of CD53 in Hematopoietic Development, Stress, and Malignancy, Zev Joshua Greenberg

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Single-Cell Resolution Mechanistic Analyses of Direct Lineage Reprogramming, Chuner Guo

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Understanding the Molecular Mechanisms of Photoferrotrophy and Phototrophic Extracellular Electron Uptake, Dinesh Gupta

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Thermodynamics and Conformational Heterogeneity of RecBCD Binding to DNA Ends, Linxuan Hao

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Linking Neuronal Protein Phosphatase 2A to the DLK Stress Kinase Signaling Cascade, Margaret Hayne

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Dendritic Processing and Efficient Coding in the Retina, Jen-Chun Hsiang

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The Roles of Capsular Polysaccharides and Diet in the Immune Response to a Bacteroides thetaiotaomicron Antigen, Samantha Hsieh

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Dissecting the Role and Regulation of Transcription Factor Zeb2 in Hematopoiesis, Xiao Huang

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The immunoregulation of autoimmune diabetes, Hao Hu

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Retinal Ganglion Cells Underlying Visual Perception and Predation in Mice, Keith Patrick Johnson

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Method Development for Enhancing Sensitivity of Dynamic Nuclear Polarization Nuclear Magnetic Resonance Spectroscopy for Structural Studies of PKC-Drug Interactions, Patrick Terrence Judge

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Etv2/Myct1 axis in the regulation of tumor angiogenesis and anti-tumor immunity, Ashraf Ul Kabir

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Copper-mediated Regulation of a Traditional Iron Uptake System in Uropathogenic Escherichia coli., George Lwanga Katumba

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The Role of Excited States in Determining β-lactamase Function and Bacterial Fitness, Catherine Rae Knoverek

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Influence of Aging and Cerebrovascular Disease on Neuroimaging Measures of Alzheimer Disease, Lauren Nicole Koenig

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Gut Reactions: Quantitative Predictions of the Responses of Human Gut Microbiota to Medical Interventions, Amy Elizabeth Langdon

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Stem Cell Models to Study the Regulation of Human Cortical Development and Its Disruption in Neurodevelopmental Disorders, Emily Megan Alexandra Lewis

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Identify Genetic and Epigenetic Abnormalities Associated with Therapeutic Vulnerability in Human Cancers, Wen-Wei Liang

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Regulation of transcription factor binding specificity: from binding motifs to local DNA context, Jiayue Liu

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Vestibulospinal circuit in the larval zebrafish, Zhikai Liu

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Type I Interferon Regulation of Chikungunya Virus Pathogenesis, Marissa Christine Locke

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Regulation, Architecture, and Function of the Type VI Secretion System of Acinetobacter baumannii, Juvenal Lopez

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The Phylogeography of Rare Central Tennessee Glade Endemics Trifolium calcaricum and Viola egglestonii, Rachel Ann Lyman

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Transcriptional and Epigenetic Regulation of Cerebellar Development and Function, Shahriyar Majidi

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Dissecting the neural circuits mediating pain-induced negative affect and drug-seeking behaviors, Tamara Markovic

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Deep Learning Deleterious Small Molecule Biochemistry from the Lab to the Clinic, Matthew Matlock

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Investigation of IFNγ-induced Control of Intracellular Pathogens, Michael Mcallaster

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Ascension and Adhesion of Uropathogenic Escherichia coli during Pyelonephritis, Lisa Kristine McLellan

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Modularity of Feedback for State-Dependent Guidance of Navigation in Mouse Visual Cortex, Andrew M. Meier

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The Role of Subclonal Gene Mutations During Progression from Myelodysplastic Syndrome to Secondary Acute Myeloid Leukemia, Andrew John Menssen

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A Novel Function of Plasmacytoid Dendritic Cells in Regulating Type 2 Immune Responses, Hannah Leigh Miller

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Prodrug Activation in Staphylococci and the Implications for Antimicrobial Development, Justin J. Miller

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Exploring β-cell Function and Heterogeneity in Obese SM/J Mice, Mario Alejandro Miranda

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The roles of plasmepsins IX and X in malaria parasite biology, Armiyaw Sebastian Nasamu

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The evolving mammalian 3D epigenome, Mayank Choudhary Nishikant Choudhary

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Metabolic Control and Immune Barriers of Hematopoietic Stem Cells, Hannah Pizzato

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Regulation of Host-Microbe Interactions in Autoimmunity and Antiviral Immunity by Cytosolic Nucleic Acid Sensing and Interferon Signaling, Derek Jerome Platt

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RNA Polymerase Binding Protein A (RbpA) Regulation of Mycobacteria Transcription and Sensitivity to Fidaxomicin, Jerome Prusa

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Genetic Variations in the Regulation and Biosynthesis of Polycyclic Tetramate Macrolactams, Yunci Qi

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The Role of Mature Secretory Cells in Gastrointestinal Regeneration, Megan Deanna Radyk

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Functional Optical Imaging of the Developing Mouse Cortex in Health and Disease, Rachel Marlene Rahn

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Comprehensive Characterization of the Genetic and Neoantigen Landscapes of Follicular Lymphoma Patients Supports the Feasibility of Personalized Cancer Vaccine Treatments, Cody Alexander Ramirez

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Targeting the PHGDH-mTOR Metabolic Axis in Osteosarcoma, Richa Rathore

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On Arousal and the Internal Regulation of Brain Function: Theory and Evidence across Modalities and Species, Ryan Raut

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Exploring the intrinsic and extrinsic factors that regulate breast cancer cell dormancy, Qihao Ren

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The Origins & Functional Effects of Postzygotic Mutations Throughout the Human Lifespan, Nicole Briana Rockweiler

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Discovery of Sex Differences in Response to p53 Loss and Gain-of-Function in Glioblastoma, Nathan Cuyle Rockwell

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Role of Secretory Leukocyte Protease Inhibitor in Urinary Tract Infection, Anne Rosen

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Investigating the Role of Bladder Epithelial Stem Cells in Bladder Mucosal Remodeling and Defense Against Infection, Seongmi Kim Russell

Regulation of Gut Commensal-Specific T Cell Differentiation by Dendritic Cell Subsets, Emilie Russler-Germain

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Measuring and Manipulating Tension-Dependent Behavior of Mechanosensitive Ion Channels, Angela M. Schlegel

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Structural Variants Are a Major Source of Gene Expression Differences in Humans and Often Affect Multiple Nearby Genes, Alexandra Jane Scott

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Precision Diffusion Imaging to Analyze Individual-Specific Plasticity, Nicole Andrea Seider

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Relating Spontaneous Activity and Cognitive States via NeuroDynamic Modeling, Matthew Singh

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Understanding and Exploiting Protein Allostery and Dynamics Using Molecular Simulations, Sukrit Singh

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Characterizing a Novel Metabolic Pathogenic Mechanism in Familial Hemiplegic Migraine, Sarah Elizabeth Smith

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Glial inflammatory responses regulate neurocognitive recovery following viral encephalitis, Allison Luen Soung

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Structural Analysis and Vaccine Efficacy of Hla mutants, Kelly Tomaszewski

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Uncovering a MYC-driven Tumor-suppressive Program in Proliferating Lymphocytes, Elena Tonc

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Investigating the differentiation and functional maturation of stem cell-derived β cells, Leonardo Velazco-Cruz

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Mechanisms of Natural Killer Cell Anti-Tumor Function and Homeostasis, Julia Alexandra Wagner

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Peripheral Nerve Macrophages and Their Implications in Neuroimmunity, Peter Leon Wang

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Regional Reprogramming and the Small Intestine: Analysis and Modeling of Adaptive Regeneration of the Epithelium, Sarah Elizabeth Waye

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Of Mice and Toddlers: A Cross-Species Investigation of the Social Motivation Theory of Autism, Claire Weichselbaum

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Computational Analysis of Non-CpG DNA Methylation in the Mammalian Nervous System, Dennis Yawen Wu

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Apolipoprotein E Immunotherapy for the Preclinical Treatment of Alzheimer Disease and Cerebral Amyloid Angiopathy, Monica Xiong

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Identification of Multi-tissue Protein Quantitative Trait Loci and Causal Inference of Protein Effects in Neurological and Other Complex Human Diseases via Mendelian Randomization, Chengran Yang