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Theses/Dissertations from 2023

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Bioinformatic tools to alleviate the annotation bottleneck within precision oncology, Erica Kay Barnell

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Maternal-Fetal Circadian Communication during Pregnancy, Keenan Bates

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Understanding the Spectrum of DNMT3A Mutations in Neurodevelopmental Disease, Diana Christian Beard

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Mechanisms and Consequences of Microtubule-Based Symmetry Breaking in Plant Roots, Natasha Anriel Bilkey

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Wide-field optical imaging of neurological disorders and sleep in mice, Lindsey M. Brier

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Multi-Scalar Contributions to Sex Differences in Brain Tumor Incidence and Outcome, Lauren Broestl

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Dissecting Tau Isoform Control and Modeling Tauopathies in Directly-Reprogrammed Neurons, Lucia Capano

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Identifying the Molecular Fate Logic Underlying Direct Neuronal Conversion, Kitra Cates

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UvrD1 Helicase of Mycobacterium tuberculosis that can be Activated by Multiple Unique Mechanisms, Ankita Chadda

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The role of the neurodevelopmental disorder gene Myt1l in mammalian brain development, Jiayang Chen

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Assessment of Cross-protective Responses to Emerging Variant Viruses, Rita Elaine Chen

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An Evolving View of Host-Microbiome Co-Development in Healthy and Undernourished Children, Robert Yuzen Chen

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Restoring the Mechanoresponsiveness of Aged Bone to Mechanical Loading, Christopher John Chermside-Scabbo

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The Microbes Within: Pathogen In-Host Adaptation and the Gut Microbiome During Persistent Colonization and Recurrent Infection, Joohee Choi

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ZFP36 Family-Mediated Post-Transcriptional and Bhlhe40-Mediated Transcriptional Regulation of T Cell Responses, Melissa Erin Cook

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Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments, Matthew Alberto Cruz

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Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments, Matthew Alberto Cruz

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Single-molecule Spectroscopy of the SARS-CoV-2 Nucleocapsid Protein, Jasmine Cubuk

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Cardiovascular SARS-CoV-2 Tropism and Immunopathology, Oleksandr Dmytrenko

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The Evolution of Transposable Elements as Cis-Regulatory Elements in Mammals, Alan Y. Du

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Investigating Cassava Susceptibility to Xanthomonas Induced Bacterial Blight Using Disease Phenotyping and Genome Engineering Strategies, Kiona Rajene Elliott

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Wild Plant–Pathogen Interactions Across Gradients of Urbanization and Latitude, Quinn N. Fox

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Iterative Machine Learning of a Cis-Regulatory Grammar, Ryan Z. Friedman

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Characterization of Subcellular Functional Domains in the Vesicular Glutamate Transporter 3-Expressing Retinal Amacrine Cell using Correlative Light and Electron Microscopy, Karl Friedrichsen

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TRPM5's Role in Vascular Development, Megan Goeckel

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Circumventing Drug Resistance with Small Molecule Inhibitors of Mycobacterium tuberculosis, Gregory Alexander Harrison

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Function and Regulation of Virulence-Associated Siderophores in Uropathogenic Enterobacterales, James Robert Heffernan

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Biotic Interactions and the Maintenance of Biodiversity across a Tropical Elevational Gradient, David Henderson

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Individual and Social Influences on Cigarette Smoking During Pregnancy, Alexandra Noel Houston-Ludlam

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Fluorescent-based Approaches for Quantifying Bacterial Transcription Initiation Kinetics, Drake Jensen

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Zebrafish Swim Capacity, Gait, and Posture During Innate Spinal Cord Repair, Nicholas Oliver Jensen

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Ribosomes as Sensors: How Cells Utilize the Translational Process to Monitor Cellular Conditions, Kyusik Q. Kim

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Identification and Characterization of Targets of Metastasis in High-Grade Serous Ovarian Cancer, Emilee Nicole Kotnik

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Identification and Characterization of Targets of Metastasis in High-Grade Serous Ovarian Cancer, Emilee Nicole Kotnik

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Histamine production by airway resident Haemophilus species induces rhinitis, Michael Lint

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Evaluating the function of DNMT3A mutations associated with Acute Myeloid Leukemia and DNMT3A Overgrowth Syndrome, Yang Li

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Multi-Omics Understanding of Heterogeneity, Progression, and Therapeutic Vulnerabilities in Kidney Disease and Cancer, Yize Li

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A Mechanistic Study of ERR α/γ Agonists for Treatment of Metabolic Dysfunction in Heart Failure, Mckenna Lael Losby

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Spike-Timing-Dependent Plasticity Alters Sensory Network Connectivity, Adalee Lube

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The Role of MAVS and Interferon-Lambda in Regulating Astrovirus and Norovirus Infections, Heyde Makimaa

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The Effect of Oxytocin Receptor Genetic Variants on Oxytocin Response, Manasi Malik

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Examining Therapeutic Targets for Central Nervous System Autoimmune Disease, Sindhu Manivasagam

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Understanding Thermotolerance in Photosynthetic Cells: From Green Algae to Land Plants, Erin Marie Mattoon

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Circadian Protein BMAL1 Regulates Astrocyte Activation and Protein Degradation in Health and Disease, Celia Augusta Mckee

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Development of Myelin in Wolfram Syndrome, Olga Reine Neyman

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Roles of the Transcription Factors Bcl6, IRF2, and Notch2 in Myeloid Development, Kevin William O'Connor

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Roles of the Transcription Factors Bcl6, IRF2, and Notch2 in Myeloid Development, Kevin William O'connor

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Dynamics of Epithelial Differentiation Following Intestinal Villus Injury, Takahiro Erick Ohara

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The Regulation of Innate Lymphoid Cells, Vincent Peng

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An Investigation of Second-Site Non-Complementation among Motile Cilia Genes in Chlamydomonas reinhardtii, Gervette M. Penny

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Characterizing the Significance of polyA tracks in Gene Regulation and Disease, Geralle Norlene Powell-Rodgers

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Sources and consequences of cell-to-cell variability in gene expression, Avinash Ramu

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Identifying Molecular Targets of ADAR1 Dependency in Breast Cancer, Sua Ryu

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Influence of Environmental Gradients on Genomic Variation in Pediatric Commensals and Pathogens, Sanjam Sawhney

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Cancer Immunogenomics Approaches to Characterizing and Treating Malignant Brain Tumors, Maximilian Oswald Schaettler

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Context Dependence, Cheating, and Long-term Conflict in Social Interactions, Trey Scott

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Mapping Brain Development and Decoding Brain Activity with Diffuse Optical Tomography, Kalyan Tripathy

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The Role of NS1 in Flavivirus Immunity and Pathogenesis, Alex W. Wessel

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The influence of the gut microbiota on asthma in school-aged children and adults, Naomi Grace Wilson

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Immunity to Emerging RNA Viruses, Emma Winkler

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Improving Neoantigen Prioritization Methods for Personalized Cancer Vaccines, Huiming Xia

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Investigating Disease Progression and Therapeutic Targets in Multiple Myeloma Using Single-cell Technologies, Lijun Yao

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Mechanisms of transcription regulation by CarD in Mycobacterium, Dennis Xiaoqian Zhu

Theses/Dissertations from 2022

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The Effects of NMDA Antagonism on Neuronal Activity and Neurovascular Coupling in Non-Human Primate Cortex, Benjamin Thomas Acland

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System shock: Using -omics data to characterize biological remodeling in the microbiome, resistome, and transcriptome of bacteria, Winston Eugene Anthony

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The Relationship Between Inflammation, Metabolism and Oxidative Stress in Chondrocytes: Drivers of Osteoarthritic Changes, Manoj Arra

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Tissue Resident Macrophages Drive Fibrosis During Pancreas Inflammatory Injury and Pancreatic Ductal Adenocarcinoma, John Baer

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Antigen Presentation in Central Nervous System Antitumor Immunity, Jay Aaron Bowman-Kirigin

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Characterizing complex affective processing across age and in relation to social anxiety symptoms, M. Catalina Camacho

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The role of the neurodevelopmental disorder gene Myt1l in mammalian brain development, Jiayang Chen

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Connections between Mechanosensitive Ion Channel MSL10 and ER-Plasma Membrane Contact Sites, Jennette Marie Codjoe

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Bioinformatics and cancer genomics approaches to advance precision medicine and elucidate tumor mutational landscapes, Kelsy Cotto

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Circadian Circuitry and Glioblastoma: Interactions with Behavior, Carcinogenesis, and Clinical Practice., Anna R. Damato

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Investigating the Specification and Regulation of the Human Trophoblast Lineage Using Cell Culture Models, Chen Dong

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Control of Intestinal Turnover and Cell Death through Canonical Autophagy Pathways within Mouse and Human Epithelia, John Steven Ekman

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A structural perspective on neutralizing antibodies to flaviviruses and coronaviruses, John Michael Errico

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Fructose Promotes the Growth of Tumors through Metabolite Exchange with Non-malignant Tissues, Ronald Joseph Fowle-Grider

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Regulation and Function of Integrin β3 in Bone-Metastatic Breast Cancer Cells in the Therapeutic Setting, Gregory Chandler Fox

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Functional Analysis of Recurrent Non-Coding Variants in Human Melanoma, Paula Maria Godoy

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Functional and anatomical characterization of descending periaqueductal gray (PAG) projections and their role in pain modulation, Jose Gabriel Grajales

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The Enemy Within: An Investigation of the Intracellular Bacteria in Urinary Tract Infections, Jennie Elizabeth Hazen

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The role of Fibroblast Growth Factor-9 in influenza A virus pathogenesis, Bradley Edward Hiller

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Uncovering New Mechanisms for Indole-3-butyric Acid Metabolism and Transport in Arabidopsis thaliana, Arielle Lynne Homayouni

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Understanding gene regulation with high-throughput genome-integrated reporter assays, Clarice Hong

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Understanding Individual Cells in Zebrafish Caudal Fin Regeneration (从单细胞视角理解斑马鱼尾鳍再生历程), Yiran Hou

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Analyzing the Interconnectedness of the Human Genome, Nicholas Jacobs

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Assembly and Repair of Photosystem II, Virginia M. Johnson

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Determinants of DNA Damage Responses During B Cell Development, Rachel Leigh Johnston

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Host development and microbiota influences on norovirus infection, Elizabeth Alexandra Kennedy

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DNMT3A Regulates Hematopoietic Stem Cells via DNA Methylation-Independent Functions, Won Kyun Koh

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Unraveling Population Heterogeneity using Single-Cell Analysis, Wenjun Kong

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The Impact of Nucleolar Stress on Thymocyte Development and T Cell Acute Lymphoblastic Leukemia Transformation, Joseph Ryan Krambs

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The Role of SOXE Transcription Factors in Melanoma Initiation, Eva Tulchinsky Kramer

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Contributions of Specific Retinal Circuits and Their Respective Projections to Visual Behaviors, Jenna Mackenzie Krizan

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Techniques for Spatial Analysis of C. elegans Anatomy and Reporter Expression, Nicolette Marie Laird

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Inferring adaptation in social microbes from experimental evolution under relaxed selection, Tyler John Larsen

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Tertiary Lymphoid Tissue in the Urinary Bladder of Aging Mice and Women, Marianne Morris Ligon

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SIK3 & Wnk signals through Fray to regulate glial K+ buffering and seizure susceptibility in Drosophila models of hyperexcitability, Lorenzo Laronn Lones

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Overcoming genetic heterogeneity in glioblastoma by targeting transcriptional dependencies, Tatenda Mahlokozera

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Understanding the Influence of Individual-level Sources of Pathology Variation on Neuroimaging Measures of Alzheimer Disease, Austin Andrew McCullough