Originally Published In
Eissenberg JC, Elgin SC. The HP1 protein family: getting a grip on chromatin. Curr Opin Genet Dev. 2000;10(2):204–210. doi:10.1016/s0959-437x(00)00058-7
HP1 was first described in Drosophila as a heterochromatin-associated protein with dosage-dependent effects on heterochromatin-induced gene silencing. Recently, membership of the HP1 protein family has expanded tremendously. A number of intriguing interactions between HP1 and other proteins have been described, implicating HP1 in gene regulation, DNA replication, and nuclear architecture.
Eissenberg, J and Elgin, Sarah C.R., "The HP1 protein family: getting a grip on chromatin" (2000). Biology Faculty Publications & Presentations. 208.