Originally Published In
Grewal SI, Elgin SC. Heterochromatin: new possibilities for the inheritance of structure. Curr Opin Genet Dev. 2002;12(2):178–187. doi:10.1016/s0959-437x(02)00284-8
Significant portions of the eukaryotic genome are heterochromatic, made up largely of repetitious sequences and possessing a distinctive chromatin structure associated with gene silencing. New insights into the form of packaging, the associated histone modifications, and the associated nonhistone chromosomal proteins of heterochromatin have suggested a mechanism for providing an epigenetic mark that allows this distinctive chromatin structure to be maintained following replication and to spread within a given domain.
Grewal, Shiv and Elgin, Sarah C.R., "Heterochromatin: new possibilities for the inheritance of structure" (2002). Biology Faculty Publications & Presentations. 205.
© 2002 Elsevier Science Ltd. All rights reserved.