Originally Published In
Huisinga KL, Elgin SC. Small RNA-directed heterochromatin formation in the context of development: what flies might learn from fission yeast. Biochim Biophys Acta. 2009;1789(1):3–16. doi:10.1016/j.bbagrm.2008.08.002
A link between the RNAi system and heterochromatin formation has been established in several model organisms including Schizosaccharomyces pombe and Arabidopsis thaliana. However, the data to support a role for small RNAs and the associated machinery in transcriptional gene silencing in animal systems is more tenuous. Using the S. pombe system as a model, we analyze the role of small RNA pathway components and associated small RNAs in regulating transposable elements and potentially directing heterochromatin formation at these elements in Drosophila melanogaster.
Huisinga, Kathryn and Elgin, Sarah C.R., "Small RNA-directed heterochromatin formation in the context of development: what flies might learn from fission yeast" (2009). Biology Faculty Publications & Presentations. 195.