Author's School

Arts & Sciences

Author's Department

Biology

Document Type

Article

Publication Date

1-2009

Originally Published In

Huisinga KL, Elgin SC. Small RNA-directed heterochromatin formation in the context of development: what flies might learn from fission yeast. Biochim Biophys Acta. 2009;1789(1):3–16. doi:10.1016/j.bbagrm.2008.08.002

Abstract

A link between the RNAi system and heterochromatin formation has been established in several model organisms including Schizosaccharomyces pombe and Arabidopsis thaliana. However, the data to support a role for small RNAs and the associated machinery in transcriptional gene silencing in animal systems is more tenuous. Using the S. pombe system as a model, we analyze the role of small RNA pathway components and associated small RNAs in regulating transposable elements and potentially directing heterochromatin formation at these elements in Drosophila melanogaster.

ORCID

https://orcid.org/0000-0002-5176-2510 [Elgin]

DOI

10.1016/j.bbagrm.2008.08.002

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