Authors

Sushmita Roy
Jason Ernst
Peter Kharchenko
Pouya Kheradpour
Nicolas Negre
Matthew Eaton
Jane Landolin
Christopher Bristow
Lijia Ma
Michael Lin
Stefan Washietl
Bradley Arshinoff
Ferhat Ay
Patrick Meyer
Nicolas Robine
Nicole Washington
Luisa Di Stefano
Eugene Berezikov
Christopher Brown
Rogerio Candeias
Joseph Carlson
Adrian Carr
Irwin Jungreis
Daniel Marbach
Rachel Sealfon
Michael Tolstorukov
Sebastian Will
Artyom Alekseyenko
Carlo Artieri
Benjamin Booth
Angela Brooks
Qi Dai
Carrie Davis
Michael Duff
Xin Feng
Andrey Gorchakov
Tingting Gu, Washington University in St. Louis
Jorja Henikoff
Philipp Kapranov
Renhua Li
Heather MacAlpine
John Malone
Aki Minoda
Jared Nordman
Katsutomo Okamura
Marc Perry
Sara Powell
Nicole Riddle, Washington University in St. Louis
Akiko Sakai
Anastasia Samsonova
Jeremy Sandler
Yuri Schwartz
Noa Sher
Rebecca Spokony
David Sturgill
Marijke van Baren, Washington University in St. Louis
Kenneth Wan
Li Yang
Charles Yu
Elise Feingold
Peter Good
Mark Guyer
Rebecca Lowdon
Kami Ahmad
Justen Andrews
Bonnie Berger
Steven Brenner
Michael R. Brent, Washington University in St LouisFollow
Lucy Cherbas
Sarah C.R. Elgin, Washington University in St. LouisFollow
Thomas Gingeras
Robert Grossman
Roger Hoskins
Thomas Kaufman
William Kent
Mitzi Kuroda
Terry Orr-Weaver
Norbert Perrimon
Vincenzo Pirrotta
James Posakony
Bing Ren
Steven Russell
Peter Cherbas
Brenton Graveley
Suzanna Lewis
Gos Micklem
Brian Oliver
Peter Park
Susan Celniker
Steven Henikoff
Gary Karpen
Eric Lai
David MacAlpine
Lincoln Stein
Kevin White
Manolis Kellis

Author's School

Arts & Sciences

Author's Department

Biology

Document Type

Article

Publication Date

12-2010

Originally Published In

modENCODE Consortium, Roy S, Ernst J, et al. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science. 2010;330(6012):1787–1797. doi:10.1126/science.1198374

Abstract

To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. We have generated more than 700 data sets and discovered protein-coding, noncoding, RNA regulatory, replication, and chromatin elements, more than tripling the annotated portion of the Drosophila genome. Correlated activity patterns of these elements reveal a functional regulatory network, which predicts putative new functions for genes, reveals stage- and tissue-specific regulators, and enables gene-expression prediction. Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation.

Comments

Copyright 2010 by the American Association for the Advancement of Science; all rights reserved

ORCID

https://orcid.org/0000-0002-5176-2510 [Elgin]

DOI

10.1126/science.1198374

Included in

Biology Commons

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