Authors

Welkin Pope
Deborah Jacobs-Sera
Daniel Russell
Craig Peebles
Zein Al-Atrache
Turi Alcoser
Lisa Alexander
Matthew Alfano
Samantha Alford, Washington University in St. Louis
Nichols Amy
Marie Anderson
Alexander Anderson, Washington University in St. Louis
Andrew Ang
Manuel Ares Jr
Amanda Barber
Lucia Barker
Jonathan Barrett
William Barshop, Washington University in St Louis
Cynthia Bauerle
Ian Bayles
Katherine Belfield
Aaron Best
Agustin Borjon Jr
Charles Bowman
Christine Boyer
Kevin Bradley
Victoria Bradley
Lauren Broadway
Keshav Budwal
Kayla Busby
Ian Campbell
Anne Campbell
Alyssa Carey
Steven Caruso
Rebekah Chew
Chelsea Cockburn
Lianne Cohen
Jeffrey Corajod
Steven Cresawn
Kimberly Davis
Lisa Deng, Washington University in St Louis
Dee Denver
Breyon Dixon
Sahrish Ekram
Sarah C.R. Elgin, Washington University in St. LouisFollow
Angela Engelsen
Belle English
Marcella Erb
Crystal Estrada
Laura Filliger
Ann Findley
Lauren Forbes
Mark Forsyth
Tyler Fox
Melissa Fritz
Roberto Garcia
Zindzi George
Anne Georges
Christopher Gissendanner
Shannon Goff
Rebecca Goldstein
Kobie Gordon
Russell Green
Stephanie Guerra
Krysta Guiney-Olsen
Bridget Guiza
Leila Haghighat
Garrett Hagopian
Catherine Harmon
Jeremy Harmson
Grant Hartzog
Samuel Harvey
Siping He
Kevin He
Kaitlin Healy
Ellen Higinbotham
Erin Hildebrandt
Jason Ho
Gina Hogan
Victoria Hohenstein
Nathan Holz
Vincent Huang, Washington University in St. Louis
Ericka Hufford
Peter Hynes
Arrykka Jackson
Erica Jansen
Jonathan Jarvik
Paul Jasinto
Tuajuanda Jordan
Tomas Kasza
Murray Katelyn
Jessica Kelsey
Larisa Kerrigan
Daryl Khaw
Junghee Kim
Justin Knutter
Ching-Chung Ko
Gail Larkin
Jennifer Laroche
Asma Latif
Kohana Leuba
Sequoia Leuba
Lynn Lewis
Kathryn Loesser-Case
Courtney Long
A Javier Lopez
Nicholas Lowery
Tina Lu
Victor Mac
Isaac Masters
Jazmyn McCloud
Molly McDonough
Andrew Medenbach
Anjali Menon
Rachel Miller
Brandon Morgan
Patrick Ng, Washington University in St. Louis
Elvis Nguyen
Katrina Nguyen
Emilie Nguyen
Kaylee Nicholson
Lindsay Parnell
Caitlin Peirce
Allison Perz
Luke Peterson
Rachel Pferdehirt
Seegren Philip
Kit Pogliano
Joe Pogliano
Tamsen Polley
Erica Puopolo
Lauren Rodriguez
Hannah Rabinowitz, Washington University in St. Louis
Michael Resiss
Corwin Rhyan, Washington University in St. Louis
Yetta Robinson
Andrew Rose
Jeffrey Rubin
Jessica Ruby
Margaret Saha
James Sandoz
Judith Savitskaya
Dale Schipper
Christine Schnitzler
Amanda Schott
J Bradley Segal
Christopher Shaffer, Washington University in St. LouisFollow
Kathryn Sheldon
Erica Shepard
Jonathan Shepardson
Madav Shroff
Jessica Simmons
Erika Simms, Washington University in St. Louis
Brandy Simpson
Kathryn Sinclair
Robert Sjoholm
Ingrid Slette
Blaire Spaulding
Clark Straub
Joseph Stukey
Trevor Sughrue
Tin-Yun Tang
Lyons Tatyana
Stephen Taylor
Barbara Taylor
Louise Temple
Jasper Thompson
Michael Tokarz
Stephanie Trapani
Alexander Troum
Jonathan Tsay
Anthony Thomas Tubbs, Washington University in St. LouisFollow
Jillian Walton
Danielle Wang
Hannah Wang
John Warner
Emilie Weisser, Washington University in St. Louis
Samantha Wendler
Kathleen Weston-Hafer, Washington University in St. Louis
Hilary Whelan
Kurt Williamson
Angelica Willis
Hannah Wirtshafter
Theresa Wong
Phillip Wu
Yun jeong Yang
Brandon Yee
David Zaidins
Bo Zhang, Washington University in St. Louis
Melina Zúniga
Roger Hendrix
Graham Hatfull

Author's School

Arts & Sciences

Author's Department

Biology

Document Type

Article

Publication Date

1-2011

Originally Published In

Pope WH, Jacobs-Sera D, Russell DA, et al. Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution. PLoS One. 2011;6(1):e16329. doi:10.1371/journal.pone.0016329

Abstract

Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists.

Comments

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

ORCID

https://orcid.org/0000-0002-5176-2510 [Elgin]

DOI

10.1371/journal.pone.0016329

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

Included in

Biology Commons

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