Application of Machine Learning to Mapping and Simulating Gene Regulatory Networks

Author

Hien-haw Liow, Washington University in St. LouisFollow

Date of Award

Spring 5-15-2015

Author's School

Graduate School of Arts and Sciences

Author's Department

Mathematics

Degree Name

Doctor of Philosophy (PhD)

Degree Type

Dissertation

Abstract

This dissertation explores, proposes, and examines methods of applying modernmachine learning and Bayesian statistics in the quantitative and qualitative modeling of gene regulatory networks using high-throughput gene expression data. A semi-parametric Bayesian model based on random forest is developed to infer quantitative aspects of gene regulation relations; a parametric model is developed to predict geneexpression levels solely from genotype information. Simulation of network behavior is shown to complement regression analysis greatly in capturing the dynamics of gene regulatory networks. Finally, as an application and extension of novel approaches in gene expression analysis, new methods of discovering topological structure of gene regulatory networks are developed and shown to provide improvement over existing methods.

Language

English (en)

Chair and Committee

Edward Spitznagel

Committee Members

Barak Cohen, Renato Reres, Victor Wickerhauser

Comments

Permanent URL: https://doi.org/10.7936/K73776WC

Recommended Citation

Liow, Hien-haw, "Application of Machine Learning to Mapping and Simulating Gene Regulatory Networks" (2015). Arts & Sciences Electronic Theses and Dissertations. 405.
https://openscholarship.wustl.edu/art_sci_etds/405